{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:24:33Z","timestamp":1762521873030},"reference-count":64,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2012\u201000517"],"award-info":[{"award-number":["PIP 2012\u201000517"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Mantle cell lymphoma (MCL) is a heterogeneous B\u2010cell lymphoid malignancy where most patients follow an aggressive clinical course whereas others are associated with an indolent performance. <jats:italic>SOX4<\/jats:italic>, <jats:italic>SOX11<\/jats:italic>, and <jats:italic>SOX12<\/jats:italic> belong to <jats:italic>SOXC<\/jats:italic> family of transcription factors involved in embryonic neurogenesis and tissue remodeling. Among them, <jats:italic>SOX11<\/jats:italic> has been found aberrantly expressed in most aggressive MCL patients, being considered a reliable biomarker in the pathology. Several studies have revealed that microRNAs (miRs) from the <jats:italic>miR\u201017\u201092<\/jats:italic> cluster are among the most deregulated miRNAs in human cancers, still little is known about this cluster in MCL. In this study we screened the transcriptional profiles of 70 MCL patients for <jats:italic>SOXC<\/jats:italic> cluster and <jats:italic>miR17<\/jats:italic>, <jats:italic>miR18a<\/jats:italic>, <jats:italic>miR19b<\/jats:italic> and <jats:italic>miR92a<\/jats:italic>, from the <jats:italic>miR\u201017\u201092<\/jats:italic> cluster. Gene expression analysis showed higher <jats:italic>SOX11<\/jats:italic> and <jats:italic>SOX12<\/jats:italic> levels compared to <jats:italic>SOX4<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.0026). Moreover we found a negative correlation between the expression of <jats:italic>SOX11<\/jats:italic> and <jats:italic>SOX4<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). <jats:italic>miR17\u201092<\/jats:italic> cluster analysis showed that <jats:italic>miR19b<\/jats:italic> and <jats:italic>miR92a<\/jats:italic> exhibited higher levels than <jats:italic>miR17<\/jats:italic> and <jats:italic>miR18a<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Unsupervised hierarchical clustering revealed two subgroups with significant differences in relation to aggressive MCL features, such as blastoid morphological variant (<jats:italic>P<\/jats:italic>\u2009=\u20090.0412), nodal presentation (<jats:italic>P<\/jats:italic>\u2009=\u20090.0492), CD5<jats:sup>+<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2009=\u20090.0004) and shorter overall survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Together, our findings show for the first time an association between the differential expression profiles of <jats:italic>SOXC<\/jats:italic> and <jats:italic>miR17\u201092<\/jats:italic> clusters in MCL and also relate them to different clinical subtypes of the disease adding new biological information that may contribute to a better understanding of this pathology. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22355","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T05:34:47Z","timestamp":1458624887000},"page":"531-540","source":"Crossref","is-referenced-by-count":16,"title":["SOXC and MiR17\u201092 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma"],"prefix":"10.1002","volume":"55","author":[{"given":"Alejandro","family":"Roisman","sequence":"first","affiliation":[{"name":"Laboratorio de Gen\u00e9tica de Neoplasias Linfoides, Instituto de Medicina Experimental, 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