{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:38:11Z","timestamp":1790753891198,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>Biallelic inactivation of the tumor suppressor gene BRCA1\u2010associated protein 1 (BAP1) has been demonstrated in several cancers, but its prognostic role has not been completely explained. We aimed to investigate the risk associated with loss of BAP1 (BAP1\u2010) for all\u2010cause mortality, cancer\u2010specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS were searched from database inception until 09\/15\/2015 without language restrictions. Prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of BAP1 (BAP1+) vs. BAP1\u2010 were included. Data were summarized using risk ratios (RR) for number of deaths\/recurrences and hazard ratios (HR) for time\u2010dependent risk related to BAP1\u2010 adjusted for potential confounders. From 261 hits, 12 studies (including 13 cohorts) with 3,447 participants (BAP1\u2010: n\u2009=\u2009697; BAP1+: n\u2009=\u20092,750), with a median follow\u2010up over 60 months, were meta\u2010analyzed. Compared to BAP1+, BAP1\u2010 significantly increased all\u2010cause mortality, cancer\u2010specific mortality and risk of recurrence in all the tumor types analyzed, except for mesothelioma, in which the presence of <jats:italic>BAP1<\/jats:italic> mutations correlates with a better prognosis. Furthermore, we demonstrated that <jats:italic>BAP1<\/jats:italic> mutated colorectal and renal carcinomas are associated with high\u2010tumor grading (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and that <jats:italic>BAP1<\/jats:italic> mutated is more common in women than in men (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). In conclusion, on the basis of our meta\u2010analysis, we have demonstrated a peculiar role of BAP1 in influencing the prognosis in cancer. Thus, BAP1 could be considered as an important potential target for personalized medicine. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/gcc.22381","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T22:19:16Z","timestamp":1464214756000},"page":"741-749","source":"Crossref","is-referenced-by-count":56,"title":["Different prognostic roles of tumor suppressor gene <i>BAP1<\/i> in cancer: A systematic review with meta\u2010analysis"],"prefix":"10.1002","volume":"55","author":[{"given":"Claudio","family":"Luchini","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Public Health University and Hospital Trust of Verona Verona Italy"},{"name":"ARC\u2010NET Research Center University and Hospital Trust of Verona Verona Italy"},{"name":"Department of Pathology Santa Chiara Hospital Trento 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