{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:45Z","timestamp":1792782285262,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DRCD-APHP Biologie de transfert (biotransla10-asnafi)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    Plasma\u2010cell post\u2010transplantation lymphoproliferative disorder (PC\u2010PTLD) is a rare monomorphic PTLD entity divided into plasma cell myeloma (PCM) and plasmacytoma\u2010like lesion (PLL) PTLD. To date, there are no exhaustive published cytogenetic data on PC\u2010PTLD. We report array\u2010based comparative genomic hybridization (aCGH) of 10 cases of PCM and PLL\u2010PTLD. Patients had received kidney (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096), heart (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), lung (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) or bone marrow (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) transplantation. There were six men and median age at time of PTLD was 56.5 years (3\u201374). We identified two different cytological features, plasmacytic and plasmablastic, among six PLL and three PCM PTLD. Eight cases were associated with EBV. First line treatment was heterogeneous: rituximab alone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095), CHOP\u2010like (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093) and multiple myeloma\u2010like (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091). One patient died before any treatment. After a median follow\u2010up of 19.5 months (0\u2013150), five patients died (four from PTLD) and five were alive without evidence of disease. By aCGH, 5\/10 demonstrated a complex profile. The most frequent abnormalities were +7q (5\/10), +16q (5\/10), +17q (5\/10), +17p (4\/10), +5q (4\/10), t7 (4\/10), t9 (3\/10), del1p (3\/10). No del17p13 (TP53) were observed. Del1p32.3 (CDKN2C) was observed in 2 cases. On univariate prognostic analysis, a complex aCGH was associated with a shorter OS. Thus, cytogenetic abnormalities seem to be closely related to those reported in multiple myeloma or diffuse large B cell lymphoma. Complex aCGH constitutes an unfavorable prognostic marker and aCGH should be integrated in the evaluation of patients with PLL\/PCM\u2010PTLD. \u00a9 2016 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.22428","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T18:56:47Z","timestamp":1476730607000},"page":"221-230","source":"Crossref","is-referenced-by-count":12,"title":["Array\u2010CGH predicts prognosis in plasma cell post\u2010transplantation lymphoproliferative disorders"],"prefix":"10.1002","volume":"56","author":[{"given":"Cl\u00e9mentine","family":"Sarkozy","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Hospices Civils de Lyon, Centre Hospitalier Lyon\u2010Sud Pierre B\u00e9nite cedex 69495 France"},{"name":"INSERM1052, CNRS 5286 Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux Lyon\u20101 Pierre B\u00e9nite cedex 69495 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Institut national de recherche m\u00e9dicale (INSERM) UMR1151\/CNRS8253, Universit\u00e9 Paris Descartes Sorbonne Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Berger","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon Centre Hospitalier Lyon\u2010Sud, Service de Pathologie Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Traverse\u2010Glehen","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon Centre Hospitalier Lyon\u2010Sud, Service de Pathologie Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Ghesquieres","sequence":"additional","affiliation":[{"name":"INSERM1052, CNRS 5286 Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux Lyon\u20101 Pierre B\u00e9nite cedex 69495 France"},{"name":"Centre L\u00e9on B\u00e9rard, service d'H\u00e9matologie Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Hospices Civils de Lyon, Centre Hospitalier Lyon\u2010Sud Pierre B\u00e9nite cedex 69495 France"},{"name":"INSERM1052, CNRS 5286 Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux Lyon\u20101 Pierre B\u00e9nite cedex 69495 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bachy","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Hospices Civils de Lyon, Centre Hospitalier Lyon\u2010Sud Pierre B\u00e9nite cedex 69495 France"},{"name":"INSERM1052, CNRS 5286 Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux Lyon\u20101 Pierre B\u00e9nite cedex 69495 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