{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:17:53Z","timestamp":1790792273164,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extraskeletal myxoid chondrosarcoma (EMC) is a very rare sarcoma most often arising in the soft tissue. Rare EMC of the bone have been reported. EMC exhibits distinctive clinico\u2010pathological and genetic features; however, despite the name, it lacks any feature of cartilaginous differentiation. EMC is characterized by the rearrangement of the <jats:italic>NR4A3<\/jats:italic>, which, in most cases (about 62\u201075%), is fused with <jats:italic>EWSR1<\/jats:italic> and less frequently with other partners, including <jats:italic>TAF15<\/jats:italic> (27%), <jats:italic>TCF12<\/jats:italic> (4%), <jats:italic>TFG<\/jats:italic>, and <jats:italic>FUS<\/jats:italic>. We herein report the identification by whole\u2010transcriptome sequencing of <jats:italic>HSPA8<\/jats:italic> as a novel fusion partner of <jats:italic>NR4A3<\/jats:italic> in a case of EMC. FISH analysis confirmed the presence of a genomic <jats:italic>HSPA8\u2010NR4A3<\/jats:italic> translocation in the vast majority of tumor cells. Our findings expand the spectrum of <jats:italic>NR4A3<\/jats:italic> fusion partners involved in EMC pathobiology.<\/jats:p>","DOI":"10.1002\/gcc.22462","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T10:37:39Z","timestamp":1491475059000},"page":"582-586","source":"Crossref","is-referenced-by-count":45,"title":["<scp>HSPA<\/scp>8 as a novel fusion partner of <scp>NR<\/scp>4<scp>A<\/scp>3 in extraskeletal myxoid chondrosarcoma"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-9098","authenticated-orcid":false,"given":"Milena","family":"Urbini","sequence":"first","affiliation":[{"name":"\u201cGiorgio Prodi\u201d Cancer Research Center, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Astolfi","sequence":"additional","affiliation":[{"name":"\u201cGiorgio Prodi\u201d Cancer Research Center, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Abbondanza","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"\u201cGiorgio Prodi\u201d Cancer Research Center, University of Bologna Bologna Italy"},{"name":"Department of Specialized, Experimental and Diagnostic Medicine Sant'Orsola\u2010Malpighi Hospital, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Serravalle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cLalla Ser\u00e0gnoli\u201d Sant'Orsola\u2010Malpighi Hospital, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Paolo","family":"Dei Tos","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padua School of Medicine Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Picci","sequence":"additional","affiliation":[{"name":"Laboratory of Oncologic Research Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Indio","sequence":"additional","affiliation":[{"name":"\u201cGiorgio Prodi\u201d Cancer Research Center, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sbaraglia","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padua School of Medicine Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Benini","sequence":"additional","affiliation":[{"name":"Laboratory of Oncologic Research Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Righi","sequence":"additional","affiliation":[{"name":"Laboratory of Oncologic Research Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gambarotti","sequence":"additional","affiliation":[{"name":"Laboratory of Oncologic Research Istituto Ortopedico Rizzoli Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gronchi","sequence":"additional","affiliation":[{"name":"Melanoma and Sarcoma Unit, Department of Surgery Fondazione IRCCS Istituto Nazionale Tumori Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Colombo","sequence":"additional","affiliation":[{"name":"Melanoma and Sarcoma Unit, Department of Surgery Fondazione IRCCS Istituto Nazionale Tumori Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Dagrada","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Molecular Pathology, Department of Diagnostic Pathology and Laboratory Fondazione IRCCS Istituto Nazionale Tumori Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Pilotti","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Molecular Pathology, Department of Diagnostic Pathology and Laboratory Fondazione IRCCS Istituto Nazionale Tumori Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Maestro","sequence":"additional","affiliation":[{"name":"Oncogenetics and Functional Oncogenomics (FOGG) CRO Aviano National Cancer Institute Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Polano","sequence":"additional","affiliation":[{"name":"Oncogenetics and Functional Oncogenomics (FOGG) CRO Aviano National Cancer Institute Aviano 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Biasco","sequence":"additional","affiliation":[{"name":"\u201cGiorgio Prodi\u201d Cancer Research Center, University of Bologna Bologna Italy"},{"name":"Department of Specialized, Experimental and Diagnostic Medicine Sant'Orsola\u2010Malpighi Hospital, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Giovanni","family":"Casali","sequence":"additional","affiliation":[{"name":"Adult Mesenchymal Tumour and Rare Cancer Medical Oncology Unit, Cancer Medicine Department Fondazione IRCCS Istituto Nazionale Tumori Milan  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Stacchiotti","sequence":"additional","affiliation":[{"name":"Adult Mesenchymal Tumour and Rare Cancer Medical Oncology Unit, Cancer Medicine Department Fondazione IRCCS Istituto Nazionale Tumori Milan  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