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Other genes that may predispose to mesothelioma are\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    and DNA repair genes. Asbestos exposure has often been reported in patients with malignant pleural mesothelioma (MPM) and germline variants in\n                    <jats:italic>BAP1<\/jats:italic>\n                    , but this exposure has never been quantified. We aimed to search for germline variants in\n                    <jats:italic>BAP1<\/jats:italic>\n                    among 25 new Italian probands with suspected\n                    <jats:italic>BAP1<\/jats:italic>\n                    \u2010TPDS, summarize the prevalence of these variants in 39 Italian patients with familial MPM and other tumors recruited over a 5\u2010year period, and compare cumulative asbestos exposure in 14 patients with MPM and pathogenic germline variants in\n                    <jats:italic>BAP1<\/jats:italic>\n                    ,\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    , or DNA repair genes with that of 67 patients without germline variants in 94 cancer\u2010predisposing genes.\n                  <\/jats:p>\n                  <jats:p>\n                    We report here a new pathogenic germline variant in\n                    <jats:italic>BAP1<\/jats:italic>\n                    : c.783\u2009+\u20092 T\u2009&gt;\u2009C. The prevalence of pathogenic germline variants in\n                    <jats:italic>BAP1<\/jats:italic>\n                    was 7.7% among patients with familial MPM (3\/39). Patients with pathogenic germline variants in\n                    <jats:italic>BAP1<\/jats:italic>\n                    ,\n                    <jats:italic>CDKN2A<\/jats:italic>\n                    , or DNA repair genes showed lower cumulative asbestos exposure than patients without germline variants in 94 cancer\u2010predisposing genes (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.00002). This suggests an interaction between genetic risk factors and asbestos in the development of mesothelioma.\n                  <\/jats:p>","DOI":"10.1002\/gcc.22670","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T04:27:36Z","timestamp":1539923256000},"page":"573-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in\n                    <i>BAP1<\/i>\n                    or other DNA repair genes"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-6666","authenticated-orcid":false,"given":"Marta","family":"Betti","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aspesi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Unit of Cancer Epidemiology, CPO\u2010Piemonte University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Sculco","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisella","family":"Righi","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin at San Luigi Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Mirabelli","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology CPO\u2010Piemonte and University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin at San Luigi Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Rond\u00f3n\u2010Lagos","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Biol\u00f3gicas Universidad Pedag\u00f3gica y Tecnol\u00f3gica de Colombia  Tunja Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Casalone","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"},{"name":"Italian Institute for Genomic Medicine  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Vignolo Lutati","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit AOU Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ogliara","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit AOU Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bironzo","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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