{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:37:39Z","timestamp":1770237459209,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T\u2010cell lymphoma (pcAECyTCL) is a rare provisionally categorized cutaneous lymphoma characterized by an aggressive course. Its pathogenesis and molecular mechanisms are still unknown, and only two individual cases have so far been molecularly characterized. The aim of this study was to define the pattern of numerical chromosomal alterations in tumor samples taken from 20 patients with pcAECyTCL at the time of diagnosis by means of array\u2010comparative genomic hybridization (a\u2010CGH). a\u2010CGH detected numerous genomic aberrations in all the patients and, putting these together as a whole, they affected all the chromosomes. However, no specific profile of recurrent copy number alterations (CNAs) was found. Most of the gains involved regions previously described in other aggressive cutaneous lymphomas such as 7q, 8q24.3, and 17q, whereas the most significant CNA was the loss of 9p21.3 (<jats:italic>CDKN2A\u2013CDKN2B<\/jats:italic>), which has already been found in a variety of malignant tumors and is associated with aggressive cutaneous T\u2010cell lymphomas. In brief, CGH analysis revealed a large number of CNAs with only few recurring regions that probably do not represent driving events. The genomic instability found in this aggressive variant of cutaneous lymphoma may therefore be a secondary event but, at the time of the diagnosis of pcAECyTCL, the genomic integrity of tumor cells is already compromised.<\/jats:p>","DOI":"10.1002\/gcc.22673","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T14:11:07Z","timestamp":1539267067000},"page":"622-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Array\u2010based CGH of primary cutaneous CD8+ aggressive EPIDERMO\u2010tropic cytotoxic T\u2010cell lymphoma"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-0130","authenticated-orcid":false,"given":"Daniele","family":"Fanoni","sequence":"first","affiliation":[{"name":"Dipartimento di Fisiopatologia medico\u2010chirurgica e dei trapianti Universit\u00e1 degli Studi di Milano  Milan 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