{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:07:57Z","timestamp":1790129277389,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Mutations of <jats:italic>CTNNB1<\/jats:italic> have been implicated in tumorigenesis in many organs. However, tumors harboring a <jats:italic>CTNNB1<\/jats:italic> translocation are extremely rare and this translocation has never been reported in a uterine mesenchymal neoplasm. We report a novel translocation t(2;3)(p25;p22) involving the <jats:italic>GREB1<\/jats:italic> (intron 8) and <jats:italic>CTNNB1<\/jats:italic> (exon 3) in a uterine tumor resembling ovarian sex cord tumor (UTROSCT), which exhibited extrauterine metastasis. The translocation detected by RNA\u2010sequencing was validated by RT\u2010PCR, and resulted in nuclear expression of \u03b2\u2010catenin. Juxtapositioning with <jats:italic>GREB1<\/jats:italic>, which is overexpressed in response to estrogens, resulted in overexpression of a truncated and hypophosphorylated nuclear \u03b2\u2010catenin in the primary and recurrent tumors. This accumulation of nuclear \u03b2\u2010catenin results in a constitutive activation of the Wnt\/\u03b2\u2010catenin signaling pathway with a major oncogenic effect. The <jats:italic>CTNNB1<\/jats:italic> gene fusion, promoted by an estrogen\u2010responsive gene (<jats:italic>GREB1<\/jats:italic>), could be a potential driver of tumorigenesis in this case and a therapeutic target with adapted inhibitors. RT\u2010PCR and immunohistochemistry performed on 11 additional UTROSCTs showed no CTNNB1 fusion transcript or nuclear \u03b2\u2010catenin immunoreactivity.<\/jats:p>","DOI":"10.1002\/gcc.22694","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:09:26Z","timestamp":1540278566000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["<i>GREB1\u2010CTNNB1<\/i> fusion transcript detected by RNA\u2010sequencing in a uterine tumor resembling ovarian sex cord tumor (UTROSCT): A novel <i>CTNNB1<\/i> rearrangement"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-5418","authenticated-orcid":false,"given":"Sabrina","family":"Croce","sequence":"first","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Lesluyes","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center INSERM U1218, Institut Bergoni\u00e9  Bordeaux France"},{"name":"University of Bordeaux  Bordeaux France"},{"name":"Cancer Research Center of Toulouse Oncosarc, INSERM UMR1037  Toulouse France"},{"name":"Department of Pathology Institut Claudius Regaud, IUCT\u2010Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Delespaul","sequence":"additional","affiliation":[{"name":"University of Bordeaux  Bordeaux France"},{"name":"Cancer Research Center of Toulouse Oncosarc, INSERM UMR1037  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bonhomme","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"P\u00e9rot","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Mayeur","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Rebier","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Ben Rejeb","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Guyon","sequence":"additional","affiliation":[{"name":"Department of Surgery Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Glenn","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust  Belfast United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Floquet","sequence":"additional","affiliation":[{"name":"Department of Oncology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Querleu","sequence":"additional","affiliation":[{"name":"University of Bordeaux  Bordeaux France"},{"name":"Department of Surgery Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Chakiba","sequence":"additional","affiliation":[{"name":"Department of Oncology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Devouassoux\u2010Shisheboran","sequence":"additional","affiliation":[{"name":"Department of Pathology CHU Lyon Sud  Pierrebenite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Mery","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Claudius Regaud, IUCT\u2010Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Arnould","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre JF Leclerc, Comprehensive Cancer Center  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Averous","sequence":"additional","affiliation":[{"name":"Department of Pathology CHU Strasbourg  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Soubeyran","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-0081","authenticated-orcid":false,"given":"Sophie","family":"Le Guellec","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Toulouse Oncosarc, INSERM UMR1037  Toulouse France"},{"name":"Department of Pathology Institut Claudius Regaud, IUCT\u2010Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-2181","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Chibon","sequence":"additional","affiliation":[{"name":"Cancer Research Center of Toulouse Oncosarc, INSERM UMR1037  Toulouse France"},{"name":"Department of Pathology Institut Claudius Regaud, IUCT\u2010Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"141","volume-title":"WHO Classification of Tumours of Female Reproductive Organs","author":"Oliva ECM","year":"2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/66.3.512"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.044842"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800475"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f8120c"},{"issue":"2","key":"e_1_2_7_7_1","first-page":"229","article-title":"Uterine tumors resembling ovarian sex cord tumors: an update","volume":"27","author":"Czernobilsky B","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199809000-00006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90093-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.08.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13296"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000367"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000240"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200309000-00009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a7b9cf"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318272c612"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001138"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.027"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.010403.113126"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb912"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1784"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1787"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.09.005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0947-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22432"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3909"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.406"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0297-170"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.36.23026"},{"issue":"16","key":"e_1_2_7_34_1","first-page":"3526","article-title":"Beta\u2010catenin mutation in carcinoma of the uterine endometrium","volume":"58","author":"Fukuchi T","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003997"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22518"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gax045"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.056"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6809"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.340"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24850"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23695"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.22694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:01:31Z","timestamp":1694728891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/gcc.22694"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22694","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,7]]},"assertion":[{"value":"2018-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}