{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:57:07Z","timestamp":1773687427232,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The <jats:italic>MLLT10<\/jats:italic> (formerly <jats:italic>AF10<\/jats:italic>) gene is the fourth most common <jats:italic>KMT2A<\/jats:italic> fusion partner across all acute leukemias and requires at least 3 breaks to form an in\u2010frame <jats:italic>KMT2A\/MLLT10<\/jats:italic> fusion due to the opposite orientation of each gene. A 10\u2010year retrospective review was performed to identify individuals from all age groups that harbor <jats:italic>KMT2A\/MLLT10<\/jats:italic> fusion obtained by our <jats:italic>KMT2A\/MLLT10<\/jats:italic> dual\u2010color dual\u2010fusion fluorescence in situ hybridization (D\u2010FISH) assay. Of the 60 unique individuals identified, 31 were male and 29 were female (M:F ratio, 1.1:1) with ages ranging from 3 days to 86\u2009years (mean 21.5 years, median 5.5 years). The diagnoses included acute myeloid leukemia (AML) (49 patients, 82%), B\u2010 or T\u2010lymphoblastic leukemia\/lymphoma (7 patients, 12%), myeloid sarcoma (3 patients, 5%), and a single case (2%) of undifferentiated leukemia. Twenty\u2010seven of 49 patients (55%) with AML were in the infant or pediatric age group. Fifty\u2010three of 60 patients (88%) had <jats:italic>KMT2A\/MLLT10<\/jats:italic> D\u2010FISH signal patterns mostly consisting of single fusions. In addition, 10 (26%) of 38 patients with conventional chromosome studies had \u201cnormal\u201d (5 patients) or abnormal (5 patients) chromosome studies that lacked structural or numeric abnormalities involving chromosomes 10 or 11, implying cryptic cytogenetic mechanisms for <jats:italic>KMT2A\/MLLT10<\/jats:italic> fusion. Lastly, mate\u2010pair sequencing was performed on 4 AML cases, 2 of which had \u201cnormal\u201d chromosome studies and cryptic <jats:italic>KMT2A\/MLLT10<\/jats:italic> fusion as detected by <jats:italic>KMT2A\/MLLT10<\/jats:italic> D\u2010FISH studies, and verified the multiple breaks required to generate <jats:italic>KMT2A\/MLLT10<\/jats:italic> fusion.<\/jats:p>","DOI":"10.1002\/gcc.22741","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T20:29:57Z","timestamp":1549052997000},"page":"567-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Acute leukemias harboring <i>KMT2A\/MLLT10<\/i> fusion: a 10\u2010year experience from a single genomics laboratory"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-8000","authenticated-orcid":false,"given":"Jess F.","family":"Peterson","sequence":"first","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Sukov","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Pitel","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie A.","family":"Smoley","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reid G.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-0950","authenticated-orcid":false,"given":"James B.","family":"Smadbeck","sequence":"additional","affiliation":[{"name":"Center for Individualized Medicine\u2010Biomarker Discovery Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Vasmatzis","sequence":"additional","affiliation":[{"name":"Center for Individualized Medicine\u2010Biomarker Discovery Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole L.","family":"Hoppman","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia T.","family":"Greipp","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda B.","family":"Baughn","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"},{"name":"Division of Hematopathology, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"130","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Arber DA","year":"2017"},{"key":"e_1_2_5_3_1","first-page":"180","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Borowitz 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