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Based on the absorbed dose to the breast, an increased risk of developing breast cancer was shown in the Swedish hemangioma cohort that was treated with radium\u2010226 for skin hemangioma as infants. Here, we screened 31 primary breast carcinomas for genetic alterations using the OncoScan CNV Plus Assay to assess GI and chromothripsis\u2010like patterns associated with the absorbed dose to the breast. Higher absorbed doses were associated with increased numbers of copy number alterations in the tumor genome and thus a more unstable genome. Hence, the observed dose\u2010dependent GI in the tumor genome is a measurable manifestation of the long\u2010term effects of irradiation. We developed a highly predictive Cox regression model for overall survival based on the interaction between absorbed dose and GI. The Swedish hemangioma cohort is a valuable cohort to investigate the biological relationship between absorbed dose and GI in irradiated humans. This work gives a biological basis for improved risk assessment to minimize carcinogenesis as a secondary disease after radiation therapy.<\/jats:p>","DOI":"10.1002\/gcc.22757","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T17:21:52Z","timestamp":1554225712000},"page":"627-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiation\u2010induced genomic instability in breast carcinomas of the Swedish hemangioma cohort"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-4633","authenticated-orcid":false,"given":"Jana","family":"Biermann","sequence":"first","affiliation":[{"name":"Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy University of Gothenburg  Gothenburg 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