{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T05:51:17Z","timestamp":1774763477005,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deletions in the long arm of chromosome 7 (del(7q)) are recurrent cytogenetic aberrations in myeloid neoplasms. They occur either isolated or as part of a complex karyotype and are associated with unfavorable prognosis in certain disease entities. We performed detailed cytogenetic analysis, molecular analysis, and array comparative genomic hybridization in a cohort of 81 patients with a variety of myeloid malignancies and del(7q) as sole chromosomal alteration. In 70% (57\/81) of patients, we identified a commonly deleted region (size: 18\u2009Mb) involving the genomic region 101\u2009912.442 (7q22.1)\u2010119\u2009608.824 (7q31.31). Furthermore, in 80 patients, we analyzed 17 genes commonly mutated in myeloid neoplasms and identified high mutation frequencies in <jats:italic>ASXL1<\/jats:italic> 34% (27\/80), <jats:italic>TET2<\/jats:italic> 33% (26\/80), <jats:italic>RUNX1<\/jats:italic> 25% (20\/80), <jats:italic>DNMT3A<\/jats:italic> 25% (20\/80), while <jats:italic>TP53<\/jats:italic> was rarely affected (5%, 4\/80). <jats:italic>ASXL1<\/jats:italic> and <jats:italic>TET2<\/jats:italic> showed similar mutation frequencies across all analyzed entities while <jats:italic>RUNX1<\/jats:italic>, <jats:italic>CBL<\/jats:italic>, and <jats:italic>JAK2<\/jats:italic> were specifically mutated in patients with acute myeloid leukemia (AML), chronic myelomonocytic leukemia, and myeloproliferative neoplasms, respectively. We detected a significantly higher frequency of <jats:italic>RUNX1<\/jats:italic> (42% vs 13%, <jats:italic>P<\/jats:italic>\u2009=\u2009.0001) and <jats:italic>ASXL1<\/jats:italic> (32% vs 14%, <jats:italic>P<\/jats:italic>\u2009=\u2009.008) mutations in AML patients with del(7q) compared to other AML patients in the Medical Research Council unfavorable risk group (n\u2009=\u2009464), indicating a cooperative leukemogenic potential. Our data provide further insight into the pathomechanism of this cytogenetic subgroup.<\/jats:p>","DOI":"10.1002\/gcc.22761","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T10:19:59Z","timestamp":1555496399000},"page":"698-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations"],"prefix":"10.1002","volume":"58","author":[{"given":"Luise","family":"Hartmann","sequence":"first","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Max\u2010Lebsche\u2010Platz 31  Munich, 81377 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Max\u2010Lebsche\u2010Platz 31  Munich, 81377 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manja","family":"Meggendorfer","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Max\u2010Lebsche\u2010Platz 31  Munich, 81377 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kern","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Max\u2010Lebsche\u2010Platz 31  Munich, 81377 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Max\u2010Lebsche\u2010Platz 31  Munich, 81377 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3076-7723","authenticated-orcid":false,"given":"Anna","family":"Stengel","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Max\u2010Lebsche\u2010Platz 31  Munich, 81377 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92902-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93347-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254441"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-082404"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6394"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402713"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3343"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008676"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.25"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-397620"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.196"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.03.016"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-426965"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12964"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1036"},{"issue":"10","key":"e_1_2_7_20_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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