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Herein, we describe an additional subset of seven tumors sharing\n                    <jats:italic>NTRK3<\/jats:italic>\n                    gene rearrangements. The cohort included five females and two males (age range 1\u201067\u2009years). Tumors were located in extremities, trunk, retroperitoneum, or intra\u2010abdominal. In all tumors, fluorescence in situ hybridization (FISH) revealed rearrangements in\n                    <jats:italic>NTRK3<\/jats:italic>\n                    accompanied by\n                    <jats:italic>NTRK3<\/jats:italic>\n                    amplification in two cases. In three cases, RNA sequencing identified a fusion transcript composed of\n                    <jats:italic>NTRK3<\/jats:italic>\n                    exon 14 fused to\n                    <jats:italic>ETV6<\/jats:italic>\n                    ,\n                    <jats:italic>TFG<\/jats:italic>\n                    , and\n                    <jats:italic>TPM4<\/jats:italic>\n                    , respectively, retaining the NTRK3 kinase domain. All tumors were positive for pan\u2010TRK by immunohistochemistry (IHC). Two cases showed low\u2010 to intermediate\u2010grade histology composed of monomorphic spindle cells arranged in a patternless architecture, stromal bands, and perivascular rings of hyalinized collagen and coexpression of S100 and CD34. The remaining five cases were high\u2010grade fascicular monomorphic spindle cell sarcomas, morphologically somewhat reminiscent of either malignant peripheral nerve sheath tumors (MPNSTs) or fibrosarcomas (FSs). Two high\u2010grade\n                    <jats:italic>NTRK3<\/jats:italic>\n                    sarcomas showed aggressive clinical behavior with development of lung metastases. Identification of high\u2010grade\n                    <jats:italic>NTRK3<\/jats:italic>\n                    \u2010rearranged sarcomas is clinically important, since the development of selective\n                    <jats:italic>NTRK<\/jats:italic>\n                    inhibitors has opened new avenues for targeted therapy. Although IHC for pan\u2010TRK can be applied as a screening tool, molecular studies are recommended for a conclusive diagnosis of\n                    <jats:italic>NTRK<\/jats:italic>\n                    \u2010rearranged neoplasms.\n                  <\/jats:p>","DOI":"10.1002\/gcc.22767","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T18:46:56Z","timestamp":1558464416000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["The histologic spectrum of soft tissue spindle cell tumors with\n                    <i>NTRK3<\/i>\n                    gene rearrangements"],"prefix":"10.1002","volume":"58","author":[{"given":"Albert J.","family":"Suurmeijer","sequence":"first","affiliation":[{"name":"Department of Pathology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Shao","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University  Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8205","authenticated-orcid":false,"given":"Cristina R.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22671"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001203"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000675"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3729"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2014.12.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001055"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1093526617712639"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4701"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26433"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13348"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001194"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0184-6"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.12.003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12910"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4677"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-1075-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13666"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714448"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31701"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000564"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.134"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2509"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.164"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e31815349f5"}],"container-title":["Genes, 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