{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:57:50Z","timestamp":1791482270439,"version":"4.3.4"},"reference-count":151,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008884","name":"Edward P. Evans Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["Special Fellow Award"],"award-info":[{"award-number":["Special Fellow Award"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08 CA230319"],"award-info":[{"award-number":["K08 CA230319"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K99 CA218896"],"award-info":[{"award-number":["K99 CA218896"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006293","name":"American Society of Clinical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000982","name":"Conquer Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","award":["Scholar Award"],"award-info":[{"award-number":["Scholar Award"]}],"id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since the discovery of RNA splicing more than 40\u2009years ago, our comprehension of the molecular events orchestrating constitutive and alternative splicing has greatly improved. Dysregulation of pre\u2010mRNA splicing has been observed in many human diseases including neurodegenerative diseases and cancer. The recent identification of frequent somatic mutations in core components of the spliceosome in myeloid malignancies and functional analysis using model systems has advanced our knowledge of how splicing alterations contribute to disease pathogenesis. In this review, we summarize our current understanding on the mechanisms of how mutant splicing factors impact splicing and the resulting functional and pathophysiological consequences. We also review recent advances to develop novel therapeutic approaches targeting splicing catalysis and splicing regulatory proteins, and discuss emerging technologies using oligonucleotide\u2010based therapies to modulate pathogenically spliced isoforms.<\/jats:p>","DOI":"10.1002\/gcc.22784","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T06:23:31Z","timestamp":1563863011000},"page":"889-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-6325","authenticated-orcid":false,"given":"Justin","family":"Taylor","sequence":"first","affiliation":[{"name":"Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center  New York New York"},{"name":"Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-2416","authenticated-orcid":false,"given":"Stanley C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.8.3171"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90294-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034316"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr370"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv210"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0168-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3414"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.051"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2207"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1209"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2756"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.057919.116"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1973010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10496"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103283"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109016"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1031"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2523"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1032"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.029"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2674"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.088"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-610543"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.7379"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-400994"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17676"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16965"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087361"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0330"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4097"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4493"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409405"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408617"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3733"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0317-6"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0081-z"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.86"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1141"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14548"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16940"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad6466"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7629"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3662"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2012.08.005"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3525"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3778"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-404863"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11547"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.336"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-429696"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02536.x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3742"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10615"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.053"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004105"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.011"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2017.10.008"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22799"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl012"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001970"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015768"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.251"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.08.006"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-518886"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-390252"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-013-0407-z"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.03.020"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.04.006"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.07.003"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1514105112"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2828"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/45590"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.181016.114"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.303"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.04.008"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91363"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-480970"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3726"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7042"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812669115"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-762393"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-845602"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2018.11.001"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.08.013"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-692400"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006384"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14060"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2930"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-843771"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06063-x"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.149"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.298"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.12.029"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3970"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.07.013"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3823"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14985"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.212548.112"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14351"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.1196"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.1204"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.55.855"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.55.863"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.188"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.180"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb100356k"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.18"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.16"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2014311"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2009411"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08387.x"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15522"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.03.011"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0485"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-013-0046-5"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-7-7"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310794200"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500059y"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1752109"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116929"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00598"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.219899.113"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.002"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.001"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.05.014"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685641"},{"key":"e_1_2_9_132_1","first-page":"5195","article-title":"Phase I and pharmacokinetic study of E7070, a chloroindolyl\u2010sulfonamide anticancer agent, administered on a weekly schedule to patients with solid tumors","volume":"9","author":"Dittrich C","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0229"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050679"},{"key":"e_1_2_9_135_1","first-page":"6619","article-title":"Phase I clinical and pharmacological study of chloroquinoxaline sulfonamide","volume":"52","author":"Rigas JR","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00128-X"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3755"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2363"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.01.010"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60756-3"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03850-2"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.01.014"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/962038"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10662"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8103"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2001-2-5-reviews1015"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02355"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3970"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24049"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf5573"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.04.008"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19802"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.22784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.22784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T01:30:21Z","timestamp":1693704621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":151,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/gcc.22784"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22784","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,3]]},"assertion":[{"value":"2019-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}