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However, a significant proportion of adult ALL patients with negative MRD still relapse suggesting that other factors (ie, molecular alterations) must be considered in order to identify those patients with high risk of disease progression. We have identified partial <jats:italic>IKZF1<\/jats:italic> gene deletions and <jats:italic>CDKN2A\/B<\/jats:italic> deletions as markers of disease recurrence and poor survival in a series of uniformly treated adolescent and adult Philadelphia chromosome\u2010negative B\u2010cell progenitor ALL patients treated according to the Programa Espa\u00f1ol de Tratamientos en Hematolog\u00eda protocols. Importantly, <jats:italic>CDKN2A\/B<\/jats:italic> deletions showed independent significance of MRD at the end of induction, which points out the need for treatment intensification in these patients despite being MRD\u2010negative after induction therapy.<\/jats:p>","DOI":"10.1002\/gcc.22788","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T16:48:12Z","timestamp":1563986892000},"page":"815-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Molecular profiling refines minimal residual disease\u2010based prognostic assessment in adults with Philadelphia chromosome\u2010negative B\u2010cell precursor acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-6470","authenticated-orcid":false,"given":"Jordi","family":"Ribera","sequence":"first","affiliation":[{"name":"Institut de Recerca Contra la Leucemia Josep 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