{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:14Z","timestamp":1791919034639,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alveolar soft part sarcoma (ASPS) is a rare malignancy that, since its initial description, remains a neoplasm of uncertain histogenesis. The disease\u2010defining molecular event characterizing the diagnosis of ASPS is the <jats:italic>ASPSCR1\u2010TFE3<\/jats:italic> fusion gene. Following identification of an index case of ASPS with a novel <jats:italic>TFE3<\/jats:italic> fusion partner, we performed a retrospective review to determine whether this represents an isolated event. We identified two additional cases, for a total of three cases lacking <jats:italic>ASPSCR1<\/jats:italic> partners. The average patient age was 46\u2009years (range, 17\u201065); two patients were female. The sites of origin included the transverse colon, foot, and dura. Each case exhibited a histomorphology typical of ASPS, and immunohistochemistry was positive for TFE3 in all cases. Routine molecular testing of the index patient demonstrated a <jats:italic>HNRNPH3\u2010TFE3<\/jats:italic> gene fusion; the remaining cases were found to have <jats:italic>DVL2\u2010TFE3<\/jats:italic> or <jats:italic>PRCC\u2010TFE3<\/jats:italic> fusion products. The latter two fusions have previously been identified in renal cell carcinoma; to our knowledge, this is the first report of a <jats:italic>HNRNPH3\u2010TFE3<\/jats:italic> gene fusion. These findings highlight a heretofore underrecognized genetic diversity in ASPS, which appears to more broadly molecularly overlap with that of translocation\u2010associated renal cell carcinoma and PEComa. These results have immediate implications in the diagnosis of ASPS since assays reliant upon <jats:italic>ASPSCR1<\/jats:italic> may yield a false negative result. While these findings further understanding of the molecular pathogenesis of ASPS, issues related to the histogenesis of this unusual neoplasm remain unresolved.<\/jats:p>","DOI":"10.1002\/gcc.22803","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T15:48:05Z","timestamp":1566402485000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Genetic diversity in alveolar soft part sarcoma: A subset contain variant fusion genes, highlighting broader molecular kinship with other MiT family tumors"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C.","family":"Dickson","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Health System  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine T.\u2010S.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Paediatric Laboratory Medicine Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hurlbut","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Marrano","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Department of Paediatric Laboratory Medicine Hospital for Sick Children  Toronto Ontario 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