{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:06:03Z","timestamp":1747148763599,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An extragonadal yolk sac tumor (YST) is a rare malignant germ cell tumor that usually occurs in childhood. The pathogenesis of extragonadal YST remains largely unknown, especially with regards to its cell of origin. Herein, we report a case of extragonadal YST arising in the uterine round ligament. A 31\u2010year\u2010old Japanese woman, para 2, underwent partial resection of a left\u2010sided, 5\u2010cm, solid inguinal mass. Intraoperative findings showed enlargement of the uterine round ligament in the inguinal canal. Pathological evaluation diagnosed the mass as YST with a mature teratoma (MT) component. The preoperative \u03b1\u2010fetoprotein level was markedly elevated, at 24\u2009790\u2009ng\/mL. Postoperative magnetic resonance imaging revealed a right ovarian MT and a 3\u2010cm mass remaining in the left lower abdominal wall. The patient underwent total abdominal hysterectomy, bilateral adnexectomy, and left inguinal mass resection. We sampled three frozen tissues (YST, right ovarian MT, and left normal ovary) and performed a single nucleotide polymorphism (SNP) array. Pathological evaluation revealed remnant extragonadal YST in the left inguinal region. The SNP array demonstrated a completely homozygous YST genotype. Copy number variations were gains of 1p, 1q, 2p, 3p, 7p, 8p, 10q, 14q, 18p, 20q, Xp, and Xq and losses of 12q, 20p, and Xq. The right ovarian MT and left normal ovary were partially homozygous and heterozygous, respectively. The evidence suggests that this neoplasm is presumed to be a postmeiotic germ cell origin.<\/jats:p>","DOI":"10.1002\/gcc.22817","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T04:45:46Z","timestamp":1571633146000},"page":"209-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An extragonadal yolk sac tumor presumed to be of postmeiotic germ cell origin by genetic zygosity analysis via single nucleotide polymorphism array"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-1897","authenticated-orcid":false,"given":"Daisuke","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"},{"name":"Department of Gynecology Akita Red Cross Hospital  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Clinical Genomics, Graduate School of Medicine Osaka University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Shirasawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiteru","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Cellular and Organ Pathology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine Akita University  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.47.1.5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000722"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.4.407"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00793.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1568"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22027"},{"key":"e_1_2_8_8_1","first-page":"1834","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Michael RG","year":"2012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07578-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.08.028"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.6.1067"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.11.2190"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22339"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1"},{"issue":"4","key":"e_1_2_8_15_1","first-page":"635","article-title":"Genetics and biology of human ovarian teratomas. 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