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Although MET arising in soft tissue, bone, or viscera share morphologic and immunophenotypic overlap with their salivary gland and cutaneous counterparts, there is still controversy regarding their genetic relationship. Half of MET of soft tissue and bone harbor <jats:italic>EWSR1<\/jats:italic> or <jats:italic>FUS<\/jats:italic> related fusions, while MET arising in the salivary gland and skin often show <jats:italic>PLAG1<\/jats:italic> and <jats:italic>HMGA2<\/jats:italic> gene rearrangements. Regardless of the site of origin, the gold standard in diagnosing a MET relies on demonstrating its \u201cmyoepithelial immunophenotype\u201d of positivity for EMA\/CK and S100 protein or GFAP. However, the morphologic spectrum of MET in soft tissue and bone is quite broad and the above immunoprofile is nonspecific, being shared by other pathogenetically unrelated neoplasms. Moreover, rare MET lack a diagnostic immunoprofile but shows instead the characteristic gene fusions. In this study, we analyzed a large cohort of 66 MET with EWSR1 and FUS gene rearrangements spanning various clinical presentations, to better define their morphologic spectrum and establish relevant pathologic\u2010molecular correlations. Genetic analysis was carried out by FISH for <jats:italic>EWSR1\/FUS<\/jats:italic> rearrangements and potential partners, and\/or by targeted RNA sequencing. Then, 82% showed <jats:italic>EWSR1<\/jats:italic> rearrangement, while 18% had <jats:italic>FUS<\/jats:italic> abnormalities. <jats:italic>EWSR1\u2010POU5F1<\/jats:italic> occurred with predilection in malignant MET in children and young adults and these tumors had nested epithelioid morphology and clear cytoplasm. In contrast, <jats:italic>EWSR1\/FUS\u2010PBX1\/3<\/jats:italic> fusions were associated with benign and sclerotic spindle cell morphology. Tumors with <jats:italic>EWSR1\u2010KLF17<\/jats:italic> showed chordoma\u2010like morphology. Our results demonstrate striking morphologic\u2010molecular correlations in MET of bone, soft tissue and viscera, which might have implications in their clinical behavior.<\/jats:p>","DOI":"10.1002\/gcc.22835","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T07:04:26Z","timestamp":1580281466000},"page":"348-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements"],"prefix":"10.1002","volume":"59","author":[{"given":"Albert J. H.","family":"Suurmeijer","sequence":"first","affiliation":[{"name":"Department of Pathology and Medical Biology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Mount Sinai Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Mount Sinai Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Shao","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8205","authenticated-orcid":false,"given":"Cristina R.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New 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