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ABL\u2010class genes). Using FISH with probes for these genes, we screened 55 pediatric and 50 adult B\u2010other cases. Three (6%) of the adult but none of the childhood B\u2010other cases were positive for ABL\u2010class aberrations. RT\u2010PCR and sequencing confirmed a rare <jats:italic>SFPQ\u2010ABL1<\/jats:italic> fusion in one adult B\u2010other case with t(1;9)(p34;q34). Only six <jats:italic>SFPQ<\/jats:italic>\u2010<jats:italic>ABL1<\/jats:italic>\u2010positive BCP ALLs have been reported, present case included. A review of these shows that all harbored fusions between exon 9 of <jats:italic>SFPQ<\/jats:italic> and exon 4 of <jats:italic>ABL1<\/jats:italic>, that the fusion is typically found in adolescents\/younger adults without hyperleukocytosis, and that <jats:italic>IKZF1<\/jats:italic> deletions are recurrent. The few patients not treated with tyrosine kinase inhibitors (TKIs) and\/or allogeneic stem cell transplantation relapsed, strengthening the notion that TKI should be added to the therapy of <jats:italic>SFPQ<\/jats:italic>\u2010<jats:italic>ABL1<\/jats:italic>\u2010positive BCP ALL.<\/jats:p>","DOI":"10.1002\/gcc.22852","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T10:34:47Z","timestamp":1587292487000},"page":"540-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>SFPQ\u2010ABL1<\/i>\u2010positive B\u2010cell precursor acute lymphoblastic leukemias"],"prefix":"10.1002","volume":"59","author":[{"given":"Andrea","family":"Biloglav","sequence":"first","affiliation":[{"name":"Division of Clinical Genetics, Department of Laboratory Medicine Lund University  Lund 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