{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:54:22Z","timestamp":1789095262804,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tuberous sclerosis genes and <jats:italic>MTOR<\/jats:italic> are increasingly being found to have important roles in novel subtypes of renal cancer, particularly emerging entities eosinophilic solid and cystic renal cell carcinoma (RCC) and high\u2010grade oncocytic renal tumor (HOT)\/RCC with eosinophilic and vacuolated cytoplasm. We report a unique renal neoplasm in a 66\u2010year\u2010old woman that initially mimicked MITF family translocation RCC due to mixed clear and eosinophilic cells, extensive stromal hyalinization, and psammoma bodies, yet which was negative for <jats:italic>TFE3<\/jats:italic> and <jats:italic>TFEB<\/jats:italic> fluorescence in situ hybridization and a next generation sequencing (NGS) gene fusion assay. Cytoplasmic stippling triggered consideration of TSC\u2010associated neoplasms, and a targeted NGS assay revealed a variant in exon 21 of <jats:italic>TSC1<\/jats:italic> resulting in c.2626G&gt;T p.(Glu876*) truncating mutation. This report adds to the morphologic spectrum of TSC\u2010related renal neoplasms, including prominent stromal hyalinization as a potentially deceptive pattern. Due to the overlap in cytoplasmic stippling between eosinophilic solid and cystic RCC and HOT\/RCC with eosinophilic and vacuolated cytoplasm, it is debatable which category this example would best fit. Further understanding of these entities and other renal neoplasms with alterations in the TSC genes will elucidate whether they should be considered a family of tumors.<\/jats:p>","DOI":"10.1002\/gcc.22860","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T04:39:00Z","timestamp":1589690340000},"page":"591-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sclerosing <scp><i>TSC1<\/i><\/scp> mutated renal cell carcinoma: An unusual pattern mimicking <scp>MITF<\/scp> family translocation renal cell carcinoma"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-1460","authenticated-orcid":false,"given":"Sean R.","family":"Williamson","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System  Detroit Michigan USA"},{"name":"Department of Pathology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cardili","sequence":"additional","affiliation":[{"name":"Department of Pathology Cancer Institute of the State of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Whiteley","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Kis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Henry Ford Health System  Detroit Michigan 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family translocation renal cell carcinomas: a 15th anniversary update","volume":"35","author":"Gandhi JS","year":"2020","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13526"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000248"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000237"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13876"},{"key":"e_1_2_6_17_1","first-page":"1","article-title":"Eosinophilic renal cell tumors with a TSC and MTOR gene mutations are morphologically and immunohistochemically heterogenous: clinicopathologic and molecular study","author":"Tjota M","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000203"}],"container-title":["Genes, Chromosomes and 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