{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:20:25Z","timestamp":1769502025793,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma is a clonal malignancy of plasma cells in the bone marrow. Risk stratification is partly based on cytogenetic findings that include abnormalities of the <jats:italic>IGH<\/jats:italic> locus as determined by fluorescence in situ hybridization (FISH), such as rearrangements that result in either standard\u2010risk or high\u2010risk gene fusions. <jats:italic>IGH<\/jats:italic> deletions have been evaluated as a group in multiple myeloma patients with respect to cumulative outcomes but have provided limited guidance. Whether these deletions have the potential to result in gene fusions and thus further stratify patients is unknown. We identified 229 <jats:italic>IGH<\/jats:italic> deletions in patients referred for plasma cell dyscrasia genetic testing over 5.5\u2009years. Follow\u2010up was conducted on 208 of the deletions with dual fusion FISH probes for standard\u2010risk (<jats:italic>IGH<\/jats:italic>\u2010<jats:italic>CCND1<\/jats:italic>) and high\u2010risk <jats:italic>IGH<\/jats:italic> gene fusions (<jats:italic>IGH<\/jats:italic>\u2010<jats:italic>FGFR3<\/jats:italic>, <jats:italic>IGH<\/jats:italic>\u2010<jats:italic>MAF<\/jats:italic>, <jats:italic>IGH<\/jats:italic>\u2010<jats:italic>MAFB<\/jats:italic>). Of all deletions identified with follow\u2010up, 44 (21%) resulted in a gene fusion as detected by FISH, 15 (7%) of which were fusion partners associated with high\u2010risk multiple myeloma. All fusion\u2010positive 3\u2032\u2010<jats:italic>IGH<\/jats:italic> deletions (6 fusions) resulted in high\u2010risk <jats:italic>IGH<\/jats:italic>\u2010<jats:italic>FGFR3<\/jats:italic> fusions. Of the 15 high\u2010risk fusion\u2010positive cases, eight were without other high\u2010risk cytogenetic findings. This study is the first to evaluate the presence of <jats:italic>IGH<\/jats:italic> gene fusions upon identification of <jats:italic>IGH<\/jats:italic> deletions and to characterize the deletion locus. Importantly, these findings indicate that follow\u2010up FISH studies with dual fusion probes should be standard of care when <jats:italic>IGH<\/jats:italic> deletions are identified in multiple myeloma.<\/jats:p>","DOI":"10.1002\/gcc.22874","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T11:10:16Z","timestamp":1590318616000},"page":"569-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High\u2010risk cytogenetics in multiple myeloma: Further scrutiny of deletions within the <scp><i>IGH<\/i><\/scp> gene region enhances risk stratification"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-6202","authenticated-orcid":false,"given":"Scott C.","family":"Smith","sequence":"first","affiliation":[{"name":"Human Genetics Laboratory, Munroe\u2010Meyer Institute for Genetics and Rehabilitation University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Althof","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory, Munroe\u2010Meyer Institute for Genetics and Rehabilitation University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavana J.","family":"Dave","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory, Munroe\u2010Meyer Institute for Genetics and Rehabilitation University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer N.","family":"Sanmann","sequence":"additional","affiliation":[{"name":"Human Genetics Laboratory, Munroe\u2010Meyer Institute for Genetics and Rehabilitation University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.02.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011442"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006-124.242"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22738"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-069625"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3257"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-631200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-650242"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2008.12.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01290.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20716"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2007.060088"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.22874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.22874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:55:28Z","timestamp":1693914928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/gcc.22874"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22874","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]},"assertion":[{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}