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Diagnostic imaging revealed a circumscribed 1.7 cm mass centred in the right antero\u2010lateral aspect of the nasopharynx. A biopsy showed a gland\u2010forming neoplasm that was in continuity with the surface epithelium. The tumor exhibited a nested to micro\u2010papillary architecture, with mild cytologic atypia. Immunohistochemistry demonstrated diffuse staining for CK7, SOX10, and p16; the abluminal layer was highlighted by CK5 and p63, while the luminal cells expressed CD117. The tumor was not amenable to subclassification and was diagnosed as a low\u2010grade nasopharyngeal adenocarcinoma, not otherwise specified (NOS). Subsequent RNA sequencing was performed which identified a novel <jats:italic>GOLGB1\u2010BRAF<\/jats:italic> fusion product. Based on its unique morphology and molecular findings, this is presumed to represent a novel subtype of nasopharyngeal adenocarcinoma. In addition to being of diagnostic relevance, this fusion may ultimately represent a potential therapeutic target.<\/jats:p>","DOI":"10.1002\/gcc.22897","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T09:09:39Z","timestamp":1600592979000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A novel low\u2010grade nasopharyngeal adenocarcinoma characterized by a <i>GOLGB1\u2010BRAF<\/i> fusion gene"],"prefix":"10.1002","volume":"60","author":[{"given":"Justin","family":"Bubola","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Faculty of Dentistry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8205","authenticated-orcid":false,"given":"Cristina R.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-3549","authenticated-orcid":false,"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"De Almeida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Department of Surgical Oncology University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"MacMillan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0787-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2011.01499.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01952.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.11.002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200101000-00009"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200109000-00009"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21203"},{"issue":"2","key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3892\/ol.2015.3314","article-title":"Epithelial\u2010myoepithelial carcinoma of the nasopharynx: a case report and review of the literature","volume":"10","author":"Kim SH","year":"2015","journal-title":"Oncol Lett"},{"issue":"1","key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1186\/s12885-018-4803-x","article-title":"Basal cell adenocarcinoma of the nasopharyngeal minor salivary glands: a case report and review of the literature","volume":"18","author":"Jin J","year":"2018","journal-title":"BMC Cancer"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25150"},{"issue":"12","key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/00000478-198812000-00005","article-title":"Nasopharyngeal papillary adenocarcinoma. 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