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The analysis of genomic profiles of uterine smooth muscle tumors shows that genomic complexity, which is an expression of chromosomal instability, correlates with the metastatic potential and malignity of tumors: the more genetically complex a smooth muscle tumor is, the more malignant is its progression. In uterine tumors with uncertain malignant potential, the assessment of genomic index by CGH array, that is, counting the genomic complexity of a tumor, allows tumors with a risk of recurrence such as leiomyosarcomas to be distinguished from benign tumors like leiomyomas. The prognosis of leiomyosarcoma is poor and the most powerful prognostic factor so far is stage, as the histologic grade is not informative. In the quest to find efficient molecular prognostic factors, the transcriptomic signature CINSARC Nanocind, a mirror of chromosomic complexity and instability, outperforms stage, in both overall and recurrence\u2010free survival. Genomic index and the CINSARC signature will contribute to improving diagnoses, therapeutic strategies, and randomization in future clinical trials. The biological understanding of the links between the CINSARC signature and metastatic mechanisms may lead to the development of new drugs. Furthermore, ctDNA is a promising new technique to detect residual disease and early recurrence.<\/jats:p>","DOI":"10.1002\/gcc.22906","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T02:44:20Z","timestamp":1603593860000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Molecular prognostication of uterine smooth muscle neoplasms: From\n                    <scp>CGH<\/scp>\n                    array to\n                    <scp>CINSARC<\/scp>\n                    signature and beyond"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-5418","authenticated-orcid":false,"given":"Sabrina","family":"Croce","sequence":"first","affiliation":[{"name":"Department of Biopathology Institut Bergoni\u00e9, Comprehensive Cancer Center Bordeaux France"},{"name":"INSERM U1218 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-2181","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Chibon","sequence":"additional","affiliation":[{"name":"Oncosarc, INSERM UMR1037, Cancer Research Center of Toulouse Toulouse France"},{"name":"Department of Pathology Institut Claudius R\u00e9gaud, IUCT\u2010Oncopole Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199406000-00001"},{"key":"e_1_2_6_3_1","unstructured":"IP P. 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