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EHE has rarely been reported to occur in the post\u2010radiotherapeutic setting, the breast site or in association with breast cancer. The differential diagnosis for radiation\u2010associated vascular lesions of the breast is classically limited to atypical vascular lesion and angiosarcoma and does not include EHE. We present the case of a woman with a history of breast cancer and post\u2010surgical radiotherapy who went on to develop an EHE of the chest wall skin within 3\u2009years of the completion of radiotherapy. Microscopically, the lesion was infiltrative and composed of anastomosing nests of epithelioid\u2010to\u2010spindled cells with eosinophilic and vacuolated cytoplasm. By immunohistochemistry, the cells were positive for ERG, D2\u201040, and CD31. The diagnosis was confirmed by identification of a characteristic <jats:italic>WWTR1<\/jats:italic>\u2010<jats:italic>CAMTA1<\/jats:italic> fusion gene using RNA sequencing. This case expands our understanding of radiation\u2010associated tumors.<\/jats:p>","DOI":"10.1002\/gcc.22912","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T15:32:22Z","timestamp":1604071942000},"page":"112-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Case of epithelioid hemangioendothelioma occurring in the postradiation setting for breast cancer"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0685-7614","authenticated-orcid":false,"given":"Elan","family":"Hahn","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of 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