{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T02:00:27Z","timestamp":1768096827994,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To our knowledge, we describe the first mesenchymal tumor with a novel GLI1\u2010FOXO4 fusion gene. This well\u2010circumscribed kidney tumor displayed variably myxoid and epithelioid histologic features with a focally nodular growth pattern. The tumor cells showed bland, round to ovoid nuclei, with no overt high\u2010grade features. The tumor showed focal immunopositivity for smooth muscle actin and Melan\u2010A, which raised the possibility of a relationship with a perivascular epithelioid cell tumor. The clinical and morphologic features appear distinct from other reported neoplasms harboring GLI1 or FOXO4 gene rearrangements. The patient underwent radical nephrectomy and is without evidence of disease during a relatively short clinical follow\u2010up period. However, the features of this tumor likely warrant long\u2010term follow\u2010up to monitor for the possibility of a late recurrence or metastasis. In addition to reporting this novel fusion\u2010positive tumor, we also provide a brief review of GLI1 and FOXO4 gene functions in both normal and neoplastic contexts.<\/jats:p>","DOI":"10.1002\/gcc.22916","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T02:49:55Z","timestamp":1604717395000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Primary myxoid and epithelioid mesenchymal tumor of the kidney with a novel <scp><i>GLI1\u2010FOXO4<\/i><\/scp> fusion"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-0417","authenticated-orcid":false,"given":"Jason R.","family":"Pettus","sequence":"first","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center, Department of Pathology and Laboratory Medicine  Lebanon New Hampshire USA"},{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darcy A.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center, Department of Pathology and Laboratory Medicine  Lebanon New Hampshire USA"},{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu V.","family":"Stan","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth, Departments of Biochemistry and Cell Biology and of Pathology and Laboratory Medicine  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie Y.","family":"Tse","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einar F.","family":"Sverrisson","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center Department of Surgery  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A.","family":"Bridge","sequence":"additional","affiliation":[{"name":"The Translational Genomics Research Institute Division of Molecular Pathology  Phoenix Arizona USA"},{"name":"University of Nebraska Medical Center Department of Pathology and Microbiology  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Linos","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center, Department of Pathology and Laboratory Medicine  Lebanon New Hampshire USA"},{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000926"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001140"},{"key":"e_1_2_7_4_1","volume-title":"WHO Classification of Tumours of the Urinary System and Male Genital Organs","author":"Moch H","year":"2016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f17ac0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i5.684"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-664649"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2012.00612.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024919"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000502"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006242"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000389"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-017-1698-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2350\/14-05-1487-CR.1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341191"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx137"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12366"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63723-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001360"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4730"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.68"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0293-x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1513-z"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2008.02.005"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.07.007"},{"issue":"16","key":"e_1_2_7_28_1","first-page":"4704","article-title":"Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions","volume":"62","author":"Barr FG","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09091.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200814"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000286"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000335"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6764"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2017.1416934"},{"issue":"5","key":"e_1_2_7_35_1","first-page":"6108","article-title":"microRNA\u2010361 inhibited prostate carcinoma cell invasion by targeting Gli1","volume":"10","author":"Chen S","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03297-w"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020147"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154048"},{"key":"e_1_2_7_39_1","first-page":"35","article-title":"Role and inhibition of GLI1 protein in cancer","volume":"9","author":"Mastrangelo E","year":"2018","journal-title":"Lung Cancer (Auckl)"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.20"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2018.01.018"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.22916","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.22916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:27:45Z","timestamp":1693880865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.22916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/gcc.22916"],"URL":"https:\/\/doi.org\/10.1002\/gcc.22916","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"assertion":[{"value":"2020-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}