{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:00:16Z","timestamp":1770739216940,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Secretory carcinomas are low\u2010grade translocation\u2010driven carcinomas occurring in patients over a wide age range. These tumors most frequently arise in the breast and salivary gland, but may occasionally arise at other anatomic sites, such as the skin, the thyroid gland or the upper or lower respiratory tract. In concert with their low\u2010grade morphology, secretory carcinomas most often follow an indolent clinical course. However, rare cases have shown dedifferentiation (also known as high\u2010grade transformation) and aggressive clinical behavior. To date, the dedifferentiated component in all molecularly confirmed cases of secretory carcinoma has taken the form of a high\u2010grade carcinoma. Here we present a case of an <jats:italic>ETV6\u2010NTRK3<\/jats:italic> fusion\u2010positive secretory carcinoma of the breast with sarcomatous dedifferentiation. The sarcomatous component showed an infantile or adult fibrosarcoma\u2010like morphology including a herringbone fascicular pattern and a hemangiopericytic vascular pattern. By immunohistochemistry, the sarcomatous component showed focal CD34 immunoreactivity and loss of all of the markers expressed in the conventional secretory carcinoma component, including SOX10, S100, GATA\u20103, AE1\/AE3 and E\u2010cadherin. Fluorescence in situ hybridization analysis revealed that the sarcomatous component retained the <jats:italic>ETV6\u2010NTRK3<\/jats:italic> fusion, but also acquired homozygous deletion of <jats:italic>CDKN2A<\/jats:italic>. The tumor followed an aggressive clinical course and the patient eventually succumbed to her disease 14\u2009months after diagnosis. The histomorphologic and molecular genetic features of this tumor are discussed, including its ability to mimic kinase\u2010rearranged infantile or adult fibrosarcomas at extramammary sites and the theragnostic importance of its distinction from conventional metaplastic spindle cell carcinomas in the breast.<\/jats:p>","DOI":"10.1002\/gcc.22929","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T15:55:26Z","timestamp":1608479726000},"page":"447-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dedifferentiated secretory breast carcinoma with fibrosarcomatous features harboring an <scp><i>ETV6\u2010NTRK3<\/i><\/scp> fusion in both components"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-0507","authenticated-orcid":false,"given":"Jin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7710-9045","authenticated-orcid":false,"given":"Paul","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin 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