{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:45:56Z","timestamp":1789472756364,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG\u201015525"],"award-info":[{"award-number":["IG\u201015525"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012101","name":"Societ\u00e0 Italiana di Ematologia Sperimentale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated <jats:italic>MYB<\/jats:italic> rearrangements (<jats:italic>MYB<\/jats:italic>\u2010R) and the levels of <jats:italic>MYB<\/jats:italic> expression, in 331 pediatric and adult patients with T\u2010cell acute lymphoblastic leukemia (T\u2010ALL). <jats:italic>MYB<\/jats:italic>\u2010R were detected in 17 cases and consisted of <jats:italic>MYB<\/jats:italic> tandem duplication (tdup) (=\u200914) or T cell receptor beta locus <jats:italic>(TRB)<\/jats:italic>\u2010<jats:italic>MYB<\/jats:italic> (=\u20093). As previously reported, <jats:italic>TRB<\/jats:italic>\u2010<jats:italic>MYB<\/jats:italic> was found only in children (1.6%) while <jats:italic>MYB<\/jats:italic> tdup occurred in both age groups, although it was slightly more frequent in children (5.2% vs 2.8%). Shared features of <jats:italic>MYB<\/jats:italic>\u2010R T\u2010ALL were a non\u2010early T\u2010cell precursor (ETP) phenotype, a high incidence of <jats:italic>NOTCH1\/FBXW7<\/jats:italic> mutations (81%) and <jats:italic>CDKN2AB<\/jats:italic> deletions (70.5%). Moreover, they mainly belonged to <jats:italic>HOXA<\/jats:italic> (=8), <jats:italic>NKX2\u20101\/2\u20102\/TLX1<\/jats:italic> (=4), and <jats:italic>TLX3<\/jats:italic> (=3) homeobox\u2010related subgroups. Overall, <jats:italic>MYB<\/jats:italic>\u2010R cases had significantly higher levels of <jats:italic>MYB<\/jats:italic> expression than <jats:italic>MYB<\/jats:italic> wild type (<jats:italic>MYB<\/jats:italic>\u2010wt) cases, although high levels of <jats:italic>MYB<\/jats:italic> were detected in ~\u200930% of <jats:italic>MYB<\/jats:italic>\u2010wt T\u2010ALL. Consistent with the transcriptional regulatory networks, cases with high <jats:italic>MYB<\/jats:italic> expression were significantly enriched within the <jats:italic>TAL\/LMO<\/jats:italic> subgroup (<jats:italic>P<\/jats:italic> =\u2009.017). Interestingly, analysis of paired diagnosis\/remission samples demonstrated that a high <jats:italic>MYB<\/jats:italic> expression was restricted to the leukemic clone. Our study has indicated that different mechanisms underlie <jats:italic>MYB<\/jats:italic> deregulation in 30%\u201040% of T\u2010ALL and highlighted that, <jats:italic>MYB<\/jats:italic> has potential as predictive\/prognostic marker and\/or target for tailored therapy.<\/jats:p>","DOI":"10.1002\/gcc.22943","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T07:29:17Z","timestamp":1613892557000},"page":"482-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<scp>MYB<\/scp> rearrangements and over\u2010expression in T\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"60","author":[{"given":"Valentina","family":"Bardelli","sequence":"first","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit University of Perugia  Perugia 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