{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:54:14Z","timestamp":1790463254260,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma cell neoplasms (PCN) and mantle cell lymphoma (MCL) can both harbor t(11;14)(q13;q32) (<jats:italic>CCND1\/IGH<\/jats:italic>), usually resulting in cyclin D1 overexpression. In some cases, particularly at low levels of disease, it can be morphologically challenging to distinguish between these entities in the bone marrow (BM) since PCN with t(11;14) are often CD20\u2010positive with lymphoplasmacytic cytology, while MCL can rarely have plasmacytic differentiation. We compared the difference in <jats:italic>CCND1<\/jats:italic>\/<jats:italic>IGH<\/jats:italic> by fluorescence in situ hybridization (FISH) in PCN and MCL to evaluate for possible differentiating characteristics. We identified 326 cases of MCL with t(11;14) and 279 cases of PCN with t(11;14) from either formalin\u2010fixed, paraffin\u2010embedded tissue or fresh BM specimens. The \u201ctypical,\u201d balanced <jats:italic>CCND1<\/jats:italic>\/<jats:italic>IGH<\/jats:italic> FISH signal pattern was defined as three total <jats:italic>CCND1<\/jats:italic> signals, three total <jats:italic>IGH<\/jats:italic> signals, and two total fusion signals. Any deviation from the \u201ctypical\u201d pattern was defined as an \u201catypical\u201d pattern, which was further stratified into \u201cgain of fusion\u201d vs \u201ccomplex\u201d patterns. There was a significantly higher proportion of cases that showed an atypical FISH pattern in PCN compared with MCL (53% vs 27%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). There was also a significantly higher proportion of cases that showed a complex FISH pattern in PCN compared with MCL (47% vs 17%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). We confirmed these findings using mate\u2010pair sequencing of 25 PCN and MCL samples. PCN more often have a complex <jats:italic>CCND1<\/jats:italic>\/<jats:italic>IGH<\/jats:italic> FISH pattern compared with MCL, suggesting possible differences in the genomic mechanisms underlying these rearrangements in plasma cells compared with B cells.<\/jats:p>","DOI":"10.1002\/gcc.22977","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T12:05:11Z","timestamp":1623672311000},"page":"678-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased complexity of t(11;14) rearrangements in plasma cell neoplasms compared with mantle cell lymphoma"],"prefix":"10.1002","volume":"60","author":[{"given":"Joanna C.","family":"Dalland","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-0950","authenticated-orcid":false,"given":"James B.","family":"Smadbeck","sequence":"additional","affiliation":[{"name":"Division of Computational Biology, Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid G.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-4897","authenticated-orcid":false,"given":"Linda B.","family":"Baughn","sequence":"additional","affiliation":[{"name":"Division of Hematopathology, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_8_3_1","volume-title":"Hematopathology","author":"Jaffe 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