{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:07:57Z","timestamp":1779199677421,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two new treatments have recently become standard care for patients with metastatic colorectal cancer (mCRC): encorafenib (BRAF inhibitor) associated with cetuximab (anti\u2010EGFR) in the second or third line of chemotherapy for <jats:italic>BRAF<\/jats:italic> V600E tumors, and pembrolizumab (an anti PD\u20101 immune checkpoint inhibitor) for tumors harboring microsatellite instability (MSI)\u2010high and\/or deficient mismatch repair (dMMR). Furthermore, 30% of <jats:italic>BRAF<\/jats:italic> V600E mutated mCRC are MSI\/dMMR through a sporadic hypermethylation of the promoter of <jats:italic>hMLH1<\/jats:italic>. We report here, for the first time, the case of a patient with <jats:italic>BRAF<\/jats:italic> V600E, <jats:italic>PIK3CA<\/jats:italic>, and <jats:italic>SMAD4<\/jats:italic> mutated and dMMR\/MSI mCRC, in whom we observed an atypical response pattern under the sequence of pembrolizumab followed by the doublet encorafenib and cetuximab treatment. The patient was progressive after a single cycle of pembrolizumab followed by a rapid complete response after only 2\u2009months of treatment with encorafenib and cetuximab, discovered during R0 cytoreduction surgery for peritoneal carcinomatosis.<\/jats:p>","DOI":"10.1002\/gcc.23012","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T08:24:13Z","timestamp":1636791853000},"page":"114-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Upfront progression under pembrolizumab followed by a complete response after encorafenib and cetuximab treatment in <scp>BRAF V600E<\/scp>\u2010mutated and microsatellite unstable metastatic colorectal cancer patient: A case report"],"prefix":"10.1002","volume":"61","author":[{"given":"Claire","family":"Gallois","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Digestive Oncology, H\u00f4pital Europ\u00e9en Georges Pompidou Paris University; 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