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However, recent literature expanded the location of\n                    <jats:italic>NUTM1<\/jats:italic>\n                    \u2010translocated malignancy to soft tissue, brain, and visceral organs. In this study, we describe the first series of six\n                    <jats:italic>NUTM1<\/jats:italic>\n                    \u2010translocated carcinomas and sarcomas occurring in the genitourinary tract. The sites of origin were kidney (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20092), bladder (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20093), and penis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20091). All tumors occurred in adulthood (range: 30\u201378\u2009years). The histologic features were heterogeneous, showing epithelial, spindle cell, or primitive small blue round cell morphology. Glandular architecture, keratinization, rhabdoid cells, or myxoid\u2010to\u2010edematous stromal component were also noted. In three cases, features were in keeping with a carcinoma (two from kidney and one from bladder), whereas the remaining three were classified as malignant undifferentiated neoplasm (MUN)\/sarcoma. Fusion partners detected in four cases tested by either FISH and\/or RNA sequencing were\n                    <jats:italic>BRD4<\/jats:italic>\n                    in two kidney tumors,\n                    <jats:italic>MXD1<\/jats:italic>\n                    in a bladder sarcoma, and\n                    <jats:italic>MXD4<\/jats:italic>\n                    in a penile sarcoma. NUT immunostain showed diffuse spiculated positivity in five cases. Immunopositivity for various cytokeratins was noted in two tumors. The outcome of\n                    <jats:italic>NUTM1<\/jats:italic>\n                    \u2010rearranged genitourinary malignancy was dismal: four of five cases with follow\u2010up developed distant metastasis, and three suffered disease\u2010specific death. In conclusion,\n                    <jats:italic>NUTM1\u2010<\/jats:italic>\n                    rearranged carcinoma and sarcoma can affect the genitourinary tract, including kidney, bladder, and penis. Histologic features and keratin immunoexpression are highly variable. A\n                    <jats:italic>NUTM1<\/jats:italic>\n                    \u2010fusion positive malignancy may be included in the differential diagnosis of a MUN of the genitourinary tract given the dismal outcome and the existing BET\u2010targeted therapy for tumors with\n                    <jats:italic>BRD3\/4::NUTM1<\/jats:italic>\n                    fusion.\n                  <\/jats:p>","DOI":"10.1002\/gcc.23046","type":"journal-article","created":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T15:33:52Z","timestamp":1650209632000},"page":"542-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>\n                      <i>NUTM1<\/i>\n                    <\/scp>\n                    \u2010fusion positive malignant neoplasms of the genitourinary tract: A report of six cases highlighting involvement of unusual anatomic locations and histologic heterogeneity"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-9835","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie\u2010Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Sarungbam","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Tickoo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-6216","authenticated-orcid":false,"given":"Brendan C.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8205","authenticated-orcid":false,"given":"Cristina R.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"304","article-title":"BRD4\u2010NUT fusion oncogene: a novel mechanism in aggressive carcinoma","volume":"63","author":"French CA","year":"2003","journal-title":"Cancer 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