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Some studies suggest that EMCs with non\u2010<jats:italic>EWSR1<\/jats:italic> variant fusion are associated with high\u2010grade morphology and worst clinical behavior compared to <jats:italic>EWSR1::NR4A3<\/jats:italic> tumors, supporting the potential significance of particular fusion variant in EMC. We report a case of a 34\u2010year\u2010old male who presented with calf EMC and subsequently developed a slowly progressive metastatic disease 3\u2009years after diagnosis. Whole\u2010transcriptome analysis with total RNA sequencing enabled identification of a novel fusion transcript <jats:italic>LSM14A::NR4A3<\/jats:italic>, expanding the molecular spectrum of EMC.<\/jats:p>","DOI":"10.1002\/gcc.23090","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T11:50:07Z","timestamp":1659786607000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A novel fusion variant <scp><i>LSM14A<\/i>::<i>NR4A3<\/i><\/scp> in extraskeletal myxoid chondrosarcoma"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-5876","authenticated-orcid":false,"given":"Carine","family":"Ngo","sequence":"first","affiliation":[{"name":"Department of Pathology and Biology Gustave Roussy  Villejuif 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