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A 46\u2010year\u2010old male patient presented with a mass involving the superficial left parotid gland with extension into the external auditory canal (EAC) and erosion of the conchal cartilage. Histologically, the neoplasm was composed of uniform spindled, epithelioid\/ovoid cells arranged in cords and nests within hyalinized to myxoid stroma. On immunohistochemistry (IHC), the tumor cells demonstrated patchy and variable staining for low molecular weight cytokeratin (CAM5.2), pan\u2010cytokeratin (OSCAR), and S\u2010100. Overall, the morphological and immunohistochemical attributes supported a locally aggressive tumor of myoepithelial differentiation consistent with myoepithelial carcinoma. Molecular analysis using a custom 115\u2010gene gene panel by targeted RNA sequencing, showed an in\u2010frame <jats:italic>CTCF::NCOA2<\/jats:italic> fusion. In addition to reporting this novel fusion in myoepithelial carcinoma, we also discuss relevant differential diagnosis, and provide a brief review of <jats:italic>NCOA2<\/jats:italic> gene function in both normal and neoplastic contexts.<\/jats:p>","DOI":"10.1002\/gcc.23101","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T15:52:15Z","timestamp":1667577135000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myoepithelial carcinoma of the parotid gland with a novel <i><scp>CTCF<\/scp>::<scp>NCOA2<\/scp><\/i> fusion"],"prefix":"10.1002","volume":"62","author":[{"given":"Jatin","family":"Gandhi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"},{"name":"Department of Laboratory Medicine and Pathology Emory University School of Medicine  Atlanta Washington 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