{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:56:21Z","timestamp":1792252581113,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes & Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>\n \n The prognosis of pediatric acute myeloid leukemia (AML) has improved via stratification therapy. However, relapse or death occurs in 30%\u201340% of cases. Novel genetic factors for pediatric AML need to be elucidated to improve prognosis. We detected recurrent internal tandem duplication in upstream binding transcription factor (\n UBTF<\/jats:italic>\n \u2010ITD) in 1.2% (6\/503) of Japanese pediatric patients with de novo AML. No\n UBTF<\/jats:italic>\n \u2010ITD was detected in 175 adult patients with AML or in 65 cell lines that included 15 AML, 39 acute lymphoblastic leukemia, five chronic myeloid leukemia, and six neuroblastoma cell lines. All\n UBTF<\/jats:italic>\n \u2010ITDs were found in exon 13 and shared a duplicated region.\n UBTF<\/jats:italic>\n \u2010ITD was more frequently detected in patients with trisomy 8,\n FLT3<\/jats:italic>\n \u2010ITD,\n WT1<\/jats:italic>\n mutation, and\/or high\n PRDM16<\/jats:italic>\n expression (trisomy 8, 3\/6;\n FLT3<\/jats:italic>\n \u2010ITD, 5\/6;\n WT1<\/jats:italic>\n mutation, 2\/6; and high\n PRDM16<\/jats:italic>\n expression, 6\/6). Gene expression patterns of patients with\n UBTF<\/jats:italic>\n \u2010ITD were similar to those of patients with\n NUP98::NSD1<\/jats:italic>\n or\n FUS::ERG<\/jats:italic>\n . Survival analysis of the AML\u201005 cohort revealed that patients with\n UBTF<\/jats:italic>\n \u2010ITD had worse outcomes than those without\n UBTF<\/jats:italic>\n \u2010ITD (3\u2010year event\u2010free survival, 20% vs. 55%; 3\u2010year overall survival, 40% vs. 74%). Moreover, among the 27 patients with trisomy 8, all three patients with\n UBTF<\/jats:italic>\n \u2010ITD had a poor prognosis resulting in early events (relapse or non\u2010complete remission) within 1 year. Our findings suggest that\n UBTF<\/jats:italic>\n \u2010ITD may be a novel and significant prognostic factor for pediatric patients with AML.\n <\/jats:p>","DOI":"10.1002\/gcc.23110","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T09:32:54Z","timestamp":1669800774000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["\n UBTF<\/i>\n \u2010internal\n <\/scp>\n tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia"],"prefix":"10.1002","volume":"62","author":[{"given":"Taeko","family":"Kaburagi","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Gunma Children's Medical Center Gunma Japan"},{"name":"Department of Pediatrics Gunma University Graduate School of Medicine Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Graduate School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genki","family":"Yamato","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Gunma Children's Medical Center Gunma Japan"},{"name":"Department of Pediatrics Gunma University Graduate School of Medicine Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology and Tumor Biology, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Tabuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-4555","authenticated-orcid":false,"given":"Kentaro","family":"Ohki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research institute for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Ishikita","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Gunma Children's Medical Center Gunma Japan"},{"name":"Department of Pediatrics Gunma University Graduate School of Medicine Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-3454","authenticated-orcid":false,"given":"Yusuke","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gunma University Graduate School of Medicine Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Division of Genome Analysis Platform Development National Cancer Center Research Institute Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohide","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Gunma Children's Medical Center Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Sotomatsu","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Gunma Children's Medical Center Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Gunma University Graduate School of Medicine Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Medical Technology Kyorin University Faculty of Health Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-2126","authenticated-orcid":false,"given":"Nobutaka","family":"Kiyokawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research institute for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-7007","authenticated-orcid":false,"given":"Daisuke","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Division of Leukemia and Lymphoma Children's Cancer Center, National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Horibe","sequence":"additional","affiliation":[{"name":"Clinical Research Center National Hospital Organization Nagoya Medical Center Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Miyano","sequence":"additional","affiliation":[{"name":"M&D Data Science Center Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shiga University of Medical Science Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Human Health Science, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Tumor Biology, Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Medicine Center for Hematology and Regenerative Medicine, Karolinska Institute Stockholm Sweden"},{"name":"Institute for the Advanced Study of Human Biology (WPI\u2010ASHBi) Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Gunma Children's Medical Center Gunma Japan"},{"name":"Institute of Physiology and Medicine Jobu University Gunma 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