{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:07:06Z","timestamp":1780553226237,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001823","name":"MEYS","doi-asserted-by":"publisher","award":["SVV 260539"],"award-info":[{"award-number":["SVV 260539"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article presents 2 cases of <jats:italic>TFG::MET<\/jats:italic>\u2010rearranged mesenchymal tumor, an extremely rare molecular subset among an emerging group of mesenchymal neoplasms with kinase gene (<jats:italic>NTRK<\/jats:italic>, <jats:italic>BRAF<\/jats:italic>, <jats:italic>RET<\/jats:italic> and others) alterations. Both tumors were congenital, occurred in female patients and presented as huge masses on the trunk and thigh, measuring 18 and 20\u2009cm in the largest dimension. Both cases showed identical areas with a distinctive triphasic morphology resembling fibrous hamartoma of infancy (FHI), consisting of haphazardly arranged ovoid to spindled cells traversed by variably cellular and hyalinized fascicles admixed with (most likely non\u2010neoplastic) adipose tissue. In other areas, a high\u2010grade infantile fibrosarcoma\/malignant peripheral nerve sheath tumor\u2010like (IFS\/MPNST\u2010like) morphology was present in both cases. While the first case co\u2010expressed CD34 and S100 protein, the other case did not. When combined with the three previously reported <jats:italic>MET<\/jats:italic>\u2010rearranged cases (of which two harbored <jats:italic>TFG::MET<\/jats:italic> fusion), 3\/5 and 3\/4 of <jats:italic>MET<\/jats:italic>\u2010rearranged and <jats:italic>TFG::MET<\/jats:italic> fusion\u2010associated tumors, respectively exhibited similar triphasic FHI\u2010like low\u2010grade morphology. This points toward the existence of a relatively distinct morphological subset among kinase\u2010fusion\u2010associated tumors which seems to be strongly associated with <jats:italic>MET<\/jats:italic> fusions. It seems some of these low\u2010grade cases may transform into a high\u2010grade variant with IFS\/MPNST\u2010like morphology as has been observed in other tumors with kinase gene fusions. While most cases seem to follow an indolent clinical course, the recognition of these tumors is clinically relevant as MET tyrosine kinase inhibitors might represent an effective treatment option for clinically aggressive or unresectable cases.<\/jats:p>","DOI":"10.1002\/gcc.23111","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T05:55:05Z","timestamp":1670219705000},"page":"290-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp><i>TFG::MET<\/i><\/scp>\u2010rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low\u2010grade triphasic morphology"],"prefix":"10.1002","volume":"62","author":[{"given":"Michael","family":"Michal","sequence":"first","affiliation":[{"name":"Department of Pathology Charles University, Faculty of Medicine in Plzen  Plzen Czech Republic"},{"name":"Bioptical Laboratory, Ltd.  Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"Ud Din","sequence":"additional","affiliation":[{"name":"Section of Histopathology, Department of Pathology and Laboratory Medicine Aga Khan University Hospital  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-4741","authenticated-orcid":false,"given":"Mari\u00e1n","family":"\u0160vajdler","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University, Faculty of Medicine in Plzen  Plzen Czech Republic"},{"name":"Bioptical Laboratory, Ltd.  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Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-8161","authenticated-orcid":false,"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[{"name":"Institute of Pathology Friedrich\u2010Alexander University Erlangen\u2010N\u00fcrnberg, University Hospital  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000675"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22846"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22671"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4701"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001203"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22877"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22972"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04650-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00806-w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14443"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00830-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001807"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01173-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22470"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a005645"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31701"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30119-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01931-y"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.19.00401"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000538"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.215"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000729"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200011000-00004"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0150-3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0557-5"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.23111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.23111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.23111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T18:32:48Z","timestamp":1692297168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.23111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/gcc.23111"],"URL":"https:\/\/doi.org\/10.1002\/gcc.23111","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]},"assertion":[{"value":"2022-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}