{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:27:20Z","timestamp":1780352840902,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyalinizing clear cell carcinoma (HCCC) is a rare salivary gland carcinoma with a generally indolent behavior, characterized by recurrent chromosomal translocation involving <jats:italic>EWSR1<\/jats:italic> (22q12.2) leading to two fusion genes <jats:italic>EWSR1::ATF1<\/jats:italic> or <jats:italic>EWSR1::CREM.<\/jats:italic> We report one case of HCCC with a novel <jats:italic>SMARCA2::CREM<\/jats:italic> fusion, identified by targeted RNA next generation sequencing by LD\u2010RT\u2010PCR, which has until now never been described in salivary glands. The exon 4 of <jats:italic>SMARCA2<\/jats:italic> is fused to exon 5 of <jats:italic>CREM<\/jats:italic>. This fusion has been described previously in only one tumor, a central nervous system tumor (intracranial mesenchymal tumor) but not in other <jats:italic>FET::CREB<\/jats:italic> fused tumors. This fusion was confirmed by <jats:italic>CREM<\/jats:italic> break\u2010apart FISH and reverse transcriptase polymerase chain reaction (RT\u2010PCR). The tumor cells showed retained expression of INI1, SMARCA2, and SMARCA4 by immunohistochemistry. We compare its clinical, histopathological, immunophenotypic, genetic features with those previously described in HCCC, <jats:italic>FET::CREB<\/jats:italic> fusion\u2010positive. Our results added data suggesting that different histomolecular tumor subtypes seem to be included within the terminology \u201cHCCC, <jats:italic>FET::CREB<\/jats:italic> fusion\u2010positive,\u201d and that further series of cases are needed to better characterize them.<\/jats:p>","DOI":"10.1002\/gcc.23114","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T09:59:56Z","timestamp":1670839196000},"page":"231-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A novel <scp><i>SMARCA2\u2010CREM<\/i><\/scp> fusion expending the molecular spectrum of salivary gland hyalinazing clear cell carcinoma beyond the <scp><i>FET<\/i><\/scp> genes"],"prefix":"10.1002","volume":"62","author":[{"given":"Marie\u2010Delphine","family":"Lanic","sequence":"first","affiliation":[{"name":"INSERM U1245, Cancer Center Henri Becquerel, Institute of Research and Innovation in Biomedicine (IRIB), University of Normandy, UNIROUEN  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sater","sequence":"additional","affiliation":[{"name":"INSERM U1245, Cancer Center Henri Becquerel, Institute of Research and Innovation in Biomedicine (IRIB), University of Normandy, UNIROUEN  Rouen France"},{"name":"Department of Pathology Centre Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Durdilly","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ruminy","sequence":"additional","affiliation":[{"name":"INSERM U1245, Cancer Center Henri 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