{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:21:04Z","timestamp":1778520064499,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal cell carcinoma (RCC) with rearrangement of transcription factor for immunoglobulin heavy\u2010chain enhancer 3 (<jats:italic>TFE3<\/jats:italic>; <jats:italic>TFE3<\/jats:italic>\u2010rearranged RCC) at Xp11.2 is a rare tumor entity but the most frequent among the microphthalmia transcription factor family translocation RCCs. Here, we report the identification of a new <jats:italic>VCP::TFE3<\/jats:italic> fusion gene as the result of a t(X;9)(p11.23;p13.3) translocation identified by whole transcriptome sequencing. No other relevant molecular alteration was identified by whole exome sequencing. This case showed typical morphological features of <jats:italic>TFE3<\/jats:italic>\u2010rearranged RCC with positive TFE3 immunostaining and positive <jats:italic>TFE3<\/jats:italic> break\u2010apart fluorescence in situ hybridization. MET was also overexpressed on immunohistochemistry. The patient had metastatic disease and was treated by surgery and five lines of therapy, including 24\u2009months of stable disease on the mesenchymal epithelial transition (MET) inhibitor cabozantinib, with an overall survival of 7\u2009years. In addition to expanding the spectrum of <jats:italic>TFE3<\/jats:italic> rearrangement partners, this report highlights the complexity of these tumors and supports the development of translational programs in renal cancer.<\/jats:p>","DOI":"10.1002\/gcc.23127","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T14:21:38Z","timestamp":1674656498000},"page":"361-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A novel <scp><i>VCP::TFE3<\/i><\/scp> gene fusion resulting from t(X;9)(p11.23;p13.3) chromosome translocation in <scp><i>TFE3<\/i><\/scp> rearranged renal cancer cell carcinoma"],"prefix":"10.1002","volume":"62","author":[{"given":"Marie Auvray","family":"Kuentz","sequence":"first","affiliation":[{"name":"Department of Oncology European Georges Pompidou Hospital, Assistance publique\u2010h\u00f4pitaux de Paris (APHP)\u2010Centre, Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Blons","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Oncology and Pharmacogenetics European Georges Pompidou Hospital, APHP\u2010Centre, Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM  Paris France"},{"name":"Centre de Recherche des Cordeliers \u2010Sorbonne Universit\u00e9\u2010 Universit\u00e9 de Paris Cit\u00e9, INSERM, Team Personalized Medicine Pharmacogenomics and Therapeutic Optimization (MEPPOT)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Paule","family":"Gimenez\u2010Roqueplo","sequence":"additional","affiliation":[{"name":"INSERM UMR 970, Paris Cardiovascular Research Center (PARCC), Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Department of Genetic European Georges Pompidou Hospital, APHP\u2010Centre, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Alexandre","family":"Just","sequence":"additional","affiliation":[{"name":"Department of Pathology H\u00f4pital Cochin, APHP\u2010Centre, Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Laurent\u2010Puig","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Molecular Oncology and Pharmacogenetics European Georges Pompidou Hospital, APHP\u2010Centre, Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM  Paris France"},{"name":"Centre de Recherche des Cordeliers \u2010Sorbonne Universit\u00e9\u2010 Universit\u00e9 de Paris Cit\u00e9, INSERM, Team Personalized Medicine Pharmacogenomics and Therapeutic Optimization (MEPPOT)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Mejean","sequence":"additional","affiliation":[{"name":"Department of Urology European Georges Pompidou Hospital, APHP\u2010Centre, Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Oudard","sequence":"additional","affiliation":[{"name":"Department of Oncology European Georges Pompidou Hospital, Assistance publique\u2010h\u00f4pitaux de Paris (APHP)\u2010Centre, Universit\u00e9 Paris Cit\u00e9, Paris Cancer Institute CARPEM  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-0236","authenticated-orcid":false,"given":"Virginie","family":"Verkarre","sequence":"additional","affiliation":[{"name":"INSERM UMR 970, Paris Cardiovascular Research Center (PARCC), Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Department 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