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Its conventional morphologic appearance manifests as a relatively well\u2010circumscribed, multilobular tumor composed of uniform short spindle\u2010to\u2010ovoid primitive mesenchymal cells with deeply eosinophilic cytoplasm arranged in anastomosing cords within abundant myxoid matrix. The genetic hallmark of EMC has long been considered to be pathognomonic gene rearrangements involving <jats:italic>NR4A3<\/jats:italic>, which when fused to <jats:italic>TAF15<\/jats:italic>, often have high\u2010grade morphology with increased cellularity, moderate to severe cytologic atypia, and rhabdoid cytomorphology. Herein, we describe two cases of EMC with <jats:italic>TAF15<\/jats:italic>::<jats:italic>NR4A3<\/jats:italic> fusion that appear morphologically distinct from both conventional and high\u2010grade EMC. Both cases had an unusual biphasic appearance and showed diffuse positivity for p63, mimicking myoepithelial tumors. DNA methylation profiling demonstrated that both cases clearly cluster with EMC, indicating that they most likely represent morphologically distinct variants of EMC. The clinical significance and prognostic impact of this morphologic variance remains to be determined. Molecular testing, including DNA methylation profiling, can help to confirm the diagnosis and avoid confusion with mimics; it adds another layer of data to support expanding the morphologic spectrum of EMC.<\/jats:p>","DOI":"10.1002\/gcc.23144","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T11:11:03Z","timestamp":1681470663000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>TAF15::NR4A3<\/i> gene fusion identifies a morphologically distinct subset of extraskeletal myxoid chondrosarcoma mimicking myoepithelial tumors"],"prefix":"10.1002","volume":"62","author":[{"given":"Laura M.","family":"Warmke","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana 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Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darcy A.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182796e46"},{"key":"e_1_2_6_3_1","volume-title":"Case 211","author":"Stewart 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