{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:16:33Z","timestamp":1783120593438,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The promyelocytic leukemia\u2010retinoic acid receptor\u2010\u03b1 (<jats:italic>PML::RARA<\/jats:italic>) fusion is the hallmark of acute promyelocytic leukemia (APL) and is observed in over 95% of APL cases. <jats:italic>RARA<\/jats:italic> and homologous receptors <jats:italic>RARB<\/jats:italic> and <jats:italic>RARG<\/jats:italic> are occasionally fused to other gene partners, which differentially affect sensitivity to targeted therapies. Most APLs without <jats:italic>RARA<\/jats:italic> fusions have rearrangements involving <jats:italic>RARG<\/jats:italic> or <jats:italic>RARB<\/jats:italic>, both of which frequently show resistance to all\u2010trans\u2010retinoic acid (ATRA) and\/or multiagent chemotherapy for acute myeloid leukemia (AML). We present a 13\u2010year\u2010old male diagnosed with variant APL with a novel <jats:italic>FNDC3B::RARB<\/jats:italic> in\u2010frame fusion that showed no response to ATRA but responded well to conventional AML therapy. While <jats:italic>FNDC3B<\/jats:italic> has been identified as a rare <jats:italic>RARA<\/jats:italic> translocation partner in ATRA\u2010sensitive variant APL, it has never been reported as a fusion partner with <jats:italic>RARB<\/jats:italic> and it is only the second known fusion partner with <jats:italic>RARB<\/jats:italic> in variant APL. We also show that this novel fusion confers an RNA expression signature that is similar to APL, despite clinical resistance to ATRA monotherapy.<\/jats:p>","DOI":"10.1002\/gcc.23180","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T17:32:23Z","timestamp":1686159143000},"page":"617-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and genomic characterization of an <scp>ATRA<\/scp>\u2010insensitive acute promyelocytic leukemia variant with a <i>FNDC3B::RARB<\/i> fusion"],"prefix":"10.1002","volume":"62","author":[{"given":"Justin K.","family":"Kirkham","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Foy","sequence":"additional","affiliation":[{"name":"Department of Computational Biology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa V.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela I.","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology James H. Quillen College of Medicine, East Tennessee State University  Johnson City Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery M.","family":"Klco","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth E.","family":"Karol","sequence":"additional","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-021-00284-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.871590"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06485-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2938"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r29"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqaa078"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0160"},{"key":"e_1_2_6_10_1","article-title":"UMAP: Uniform Manifold Approximation and Projection for dimension reduction","author":"McInnes L","year":"2018","journal-title":"arXiv"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4314"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082099299"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404376"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-767707"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-0840"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1028089"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0338-z"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040967"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70090-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.452961"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1699081"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.23070"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.497"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3466"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.23180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T10:55:34Z","timestamp":1691751334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.23180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/gcc.23180"],"URL":"https:\/\/doi.org\/10.1002\/gcc.23180","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}