{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:56:03Z","timestamp":1767826563110,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Small round cell neoplasms comprise a diverse group of tumors characterized by a primitive\/undifferentiated appearance. Although several entities are associated with recurrent gene fusions, many of these neoplasms have not been fully characterized, and novel molecular alterations are being discovered. Here, we report an undifferentiated small round cell neoplasm arising in the anterior mediastinum of a 17\u2010month\u2010old female. The tumor harbored a novel<jats:italic>HNRNPM<\/jats:italic>::<jats:italic>LEUTX<\/jats:italic>fusion resulting from chromothripsis of chromosome 19, which was identified by whole transcriptome sequencing, but not by targeted sequencing. The structural variations caused by the chromothripsis event also challenged the interpretation of the targeted sequencing findings. This report expands the spectrum of gene partners involved in<jats:italic>LEUTX<\/jats:italic>fusions and underscores the value of whole transcriptome sequencing in the diagnostic workup of undifferentiated small round cell tumors. It also highlights the interpretive challenges associated with complex genomic alterations. A careful evidence\u2010based analysis of sequencing data along with histopathologic correlation is essential to ensure correct categorization of fusions.<\/jats:p>","DOI":"10.1002\/gcc.23187","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T10:35:13Z","timestamp":1687862113000},"page":"740-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel<i><scp>HNRNPM<\/scp>::<scp>LEUTX<\/scp><\/i>fusion resulting from chromothripsis of chromosome 19 in a pediatric undifferentiated small round cell neoplasm"],"prefix":"10.1002","volume":"62","author":[{"given":"Larissa V.","family":"Furtado","sequence":"first","affiliation":[{"name":"Department of Pathology St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Pathology St. 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