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This report describes a new case of HME and capillary malformation caused by a somatic <jats:italic>AKT<\/jats:italic>3 variant that differs from the common p.E17K variant described in literature. The patient's skin biopsy from the angiomatous region revealed an heterozygous likely pathogenic variant <jats:italic>AKT3<\/jats:italic>:c.241_243dup, p.(T81dup) that may affect the binding domain and downstream pathways. Compared to previously reported cases with a common E17K mosaic variant, the phenotype is milder and patients showed segmental overgrowth, an uncommon characteristic in <jats:italic>AKT3<\/jats:italic> variant cases. These findings suggest that the severity of the disease may be influenced not only by the level of mosaicism but also by the type of variant. This report expands the phenotypic spectrum associated with <jats:italic>AKT3<\/jats:italic> variants and highlights the importance of genomic analysis in patients with capillary malformation and MCDs.<\/jats:p>","DOI":"10.1002\/gcc.23188","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T10:07:16Z","timestamp":1688378836000},"page":"703-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The somatic p.T81dup variant in <scp><i>AKT3<\/i><\/scp> gene underlies a mild cerebral phenotype and expands the spectrum including capillary malformation and lateralized overgrowth"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1239-0829","authenticated-orcid":false,"given":"Maria","family":"Luca","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Torino  Torino 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