{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:39:36Z","timestamp":1789159176381,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972520"],"award-info":[{"award-number":["81972520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>COL1A1::PDGFB<\/jats:italic> fusion uterine sarcoma is a rare uterine mesenchymal tumor with some clinicopathological features that overlap with those of soft tissue dermatofibrosarcoma protuberans. However, the varied clinicopathologic and genetic characteristics have not been fully revealed, which may be a potential pitfall for diagnosis. Here, we present a case of <jats:italic>COL1A1::PDGFB<\/jats:italic> fusion\u2010positive uterine sarcoma in a 49\u2010years\u2010old female. Histologically, the tumor from the initial marginal excision predominantly exhibited high\u2010grade fibrosarcomatous and myxofibrosarcoma\u2010like appearances, while a low\u2010grade focal area displaying storiform growth was identified in the residual tumor after subsequently extended resection. Immunohistochemically, the high\u2010grade components mainly exhibited focal positivity for CD34 and mutated\u2010type p53 immunoreactivity, whereas the low\u2010grade component showed diffuse positivity for CD34 and wild\u2010type p53 staining. The <jats:italic>COL1A1::PDGFB<\/jats:italic> fusion was confirmed by fluorescence in situ hybridization and next\u2010generation sequencing. In addition, the <jats:italic>TERT<\/jats:italic>\u2010124 C\u2009&gt;\u2009T mutation was further identified in this lesion's fibrosarcomatous and classic storiform components. To the best of our knowledge, this is the first described case of <jats:italic>COL1A1::PDGFB<\/jats:italic> fusion uterine sarcoma with a <jats:italic>TERT<\/jats:italic> promoter mutation, which might be a novel genetic finding associated with tumorigenesis of this rare tumor.<\/jats:p>","DOI":"10.1002\/gcc.23210","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T15:24:42Z","timestamp":1698074682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>COL1A1::PDGFB<\/i> fusion uterine sarcoma with a <i>TERT<\/i> promoter mutation"],"prefix":"10.1002","volume":"63","author":[{"given":"Yang","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pathology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of 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