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However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor <jats:italic>PLAG1<\/jats:italic> fusions (<jats:italic>TRPS1::PLAG1, RAD51B::PLAG1,<\/jats:italic> and <jats:italic>TRIM13::PLAG1<\/jats:italic>). In this report, we present a case of rectal MLS with a novel <jats:italic>MIR143HG::PLAG1<\/jats:italic> fusion detected by RNA next\u2010generation sequencing.<\/jats:p>","DOI":"10.1002\/gcc.23239","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T13:34:27Z","timestamp":1713965667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel <i>MIR143HG::PLAG1<\/i> gene fusion identified in a rectal myxoid leiomyosarcoma"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0441-6973","authenticated-orcid":false,"given":"Shuanzeng","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Pathology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Pathology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Belser","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Jefferson Einstein Montgomery Hospital  East Norriton Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-9704","authenticated-orcid":false,"given":"Jeffrey M.","family":"Farma","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur S.","family":"Patchefsky","sequence":"additional","affiliation":[{"name":"Department of Pathology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas B.","family":"Flieder","sequence":"additional","affiliation":[{"name":"Department of Pathology Fox Chase Cancer Center  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Miami Miller School of Medicine  Miami Florida 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