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To our knowledge, this novel gene fusion has not been described previously in salivary gland tumors. The patient presented with hoarseness of voice. The radiological exam revealed a mass in the upper third of the trachea involving the larynx. Histologically, the tumor consisted of bland\u2010looking monocellular eosinophilic epithelial cells arranged in cords and sheets separated by thin fibrous stroma, focally forming a pseudo\u2010tubular pattern. In immunohistochemistry, the tumor cells demonstrated positivity for CK7, PS100, SOX10, and HMGA2; and negativity for CK5\/6, p40 p63, and PLAG1. In addition, the clustering analysis clearly demonstrates a clustering of tumors within the PA group. In addition to reporting this novel fusion in the PA spectrum, we discuss the relevant differential diagnoses and briefly review of <jats:italic>NCOA2<\/jats:italic> and <jats:italic>WWTR1<\/jats:italic> gene functions in normal and neoplastic contexts.<\/jats:p>","DOI":"10.1002\/gcc.23244","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T10:18:31Z","timestamp":1715768311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uncovering the <i><scp>WWTR1<\/scp>::<scp>NCOA2<\/scp><\/i> Gene fusion in low\u2010grade myoepithelial\u2010rich neoplasm with <scp>HMGA2<\/scp> expression: A case report"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-2836","authenticated-orcid":false,"given":"Ziyad","family":"Alsugair","sequence":"first","affiliation":[{"name":"Department of Pathology Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Pissaloux","sequence":"additional","affiliation":[{"name":"Biopathology Department Centre Leon Berard  Lyon France"},{"name":"The Unit of Molecular Pathology, INSERM 1052, CNRS 5286 of Cancer Research Center of Lyon, and Team Genetics, Epigenetics and Biology of Sarcomas Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Descotes","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department Groupement Hospitalier Sud  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7817","authenticated-orcid":false,"given":"Franck","family":"Tirode","sequence":"additional","affiliation":[{"name":"Biopathology Department Centre Leon Berard  Lyon France"},{"name":"The Unit of Molecular Pathology, INSERM 1052, CNRS 5286 of Cancer Research Center of Lyon, and Team Genetics, Epigenetics and Biology of Sarcomas Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Lopez","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department Groupement Hospitalier Sud  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Lapierre","sequence":"additional","affiliation":[{"name":"Department of Oncological radiothERapy Centre Hospitalier Universitaire Lyon Sud  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de Strasbourg  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-9610","authenticated-orcid":false,"given":"Nazim","family":"Benzerdjeb","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut de Pathologie Multisite, Groupement Hospitalier Sud, Hospices Civils de Lyon  Pierre\u2010B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"volume-title":"Head and Neck Tumours","year":"2022","author":"WHO Classification of Tumours Editorial 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