{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:38:45Z","timestamp":1790624325319,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Urachal cancer (UC) is a rare genitourinary malignancy arising from the urachus, an embryonic remnant of the placental allantois. Its diagnosis remains ambiguous with late\u2010stage cancer detection and represents a highly aggressive disease. Due to its rarity, there is no clear consensus on molecular signatures and appropriate clinical management of UC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>We report a 45\u2010year\u2010old man with recurrent urachal adenocarcinoma (UA) treated with cystectomies, chemotherapy, and radiotherapy. The patient initially presented with hematuria and abdominal pain. Imaging revealed a nodular mass arising from the superior wall of the urinary bladder and extending to the urachus. Biopsy results suggested moderately differentiated UA with muscle layer involvement. The tumor recurred after 20\u2009months, following which, another partial cystectomy was performed. Repeat progression was noted indicating highly aggressive disease. Targeted next\u2010generation sequencing revealed the presence of <jats:italic>EIF3E<\/jats:italic>::<jats:italic>RSPO2<\/jats:italic> fusion, along with <jats:italic>BRAF<\/jats:italic> and <jats:italic>TP53<\/jats:italic> mutations, and <jats:italic>EGFR<\/jats:italic> gene amplification. This is the first case reporting the presence of this fusion in UA. Palliative medication and radiotherapy were administered to manage the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current treatment modality of surgery may be effective in the early stages of recurrent UA; however, a standard chemotherapy and radiotherapy regimen is yet to be determined for advanced stages. The detection of the rare <jats:italic>EIF3E<\/jats:italic>::<jats:italic>RSPO2<\/jats:italic> fusion warrants further studies on the significance of this variant as a possible therapeutic target for improved clinical management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/gcc.23250","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T10:41:42Z","timestamp":1718620902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of Rare <scp><i>EIF3E::RSPO2<\/i><\/scp> Fusion in Recurrent and Aggressive Urachal Adenocarcinoma"],"prefix":"10.1002","volume":"63","author":[{"given":"Prerana","family":"Jha","sequence":"first","affiliation":[{"name":"Advance Centre for Cancer Diagnostics and Research Karkinos Healthcare Pvt Ltd  Navi Mumbai Maharashtra India"},{"name":"Karkinos Foundation  Mumbai Maharashtra 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