{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T16:13:36Z","timestamp":1777738416175,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>17p13 deletions including <jats:italic>TP53<\/jats:italic> and other genes represent a common cause for reduced\/lost p53 function in tumor cells. In this study, we analyzed the impact of 17p13 (<jats:italic>TP53<\/jats:italic>) deletions and p53 expression on tumor aggressiveness and patient prognosis in urothelial carcinoma. The 17p13 copy number status was analyzed by fluorescence in situ hybridization (FISH) on more than 2700 urothelial bladder carcinomas in a tissue microarray format. 17p13 deletion data were compared to p53 expression data measured by immunohistochemistry (IHC) in a previous study. Different types of p53 alterations were compared with tumor phenotype and clinical outcome data. Deletions of 17p13 occurred in 23% of 2185 analyzable carcinomas. The fraction of tumors with 17p13 deletions increased from pTa G2 low (9%) to pTa G3 (24%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In muscle\u2010invasive carcinomas, 17p13 deletions were associated with advanced pT stage (<jats:italic>p<\/jats:italic>\u2009=\u20090.0246), but unrelated to patient prognosis (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.5). 17p13 deletions were significantly related to p53 immunostaining (<jats:italic>p<\/jats:italic>\u2009=\u20090.0375). 17p13 deletions were most common in tumors with complete lack of p53 staining (31%), which supports the concept that many of these tumors have a complete loss of p53 function (p53 null phenotype). 17p13 deletions were also increased in tumors with high p53 staining (25%). In conclusion, 17p13 deletions were most commonly seen in p53 negative cancers, supporting their role as a cause for the p53 null phenotype in urothelial cancer. The association of 17p13 deletions with high grade and advanced pT stage may reflect increasing genomic instability going along with stage and grade progression.<\/jats:p>","DOI":"10.1002\/gcc.23271","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T10:27:03Z","timestamp":1727346423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["17p13 (<i>TP53<\/i>) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-4616","authenticated-orcid":false,"given":"Martina","family":"Kluth","sequence":"first","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg 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Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Fendler","sequence":"additional","affiliation":[{"name":"Department of Urology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"de Martino","sequence":"additional","affiliation":[{"name":"Department of Urology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin and Berlin Institute of Health  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Ro\u00dfner","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Charit\u00e9 \u2013 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