{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:50:27Z","timestamp":1790524227341,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":6038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Molecular study of a t(1;14)(p32;q11) translocation found in an acute T\u2010cell leukemia (Kd cells) with a relatively mature phenotype is reported. Complex DNA rearrangements were characterized in the <jats:italic>TCR<\/jats:italic>\u03b1\/\u03b4 locus. Besides a productive V\u03b1\/J\u03b1 assembly found on the normal allele, two deletions within the J\u03b1 cluster were identified in the translocated allele. The translocation breakpoints involved the <jats:italic>TCR<\/jats:italic>\u03b1 gene on chromosome 14 and the <jats:italic>SCL<\/jats:italic> locus on chromosome band 1p32 that was recently shown to be activated by the t(1;14) translocation of the DU 528 leukemic cell line. Significantly, both Kd and DU 528 translocation breakpoints were located at the boundaries of D\u03b4 or J\u03b4 segments and were clustered in a 10 kb genomic fragment of the <jats:italic>SCL<\/jats:italic> gene. The presence of recombination signal motifs (heptamer\u201012\/23 bp spacer\u2010nonamer) on both normal chromosome partners, and N nucleotide addition on both derivative chromosomes involved the recombinase system in the translocation event. The <jats:italic>SCL<\/jats:italic> locus was highly expressed as a 5 kb transcript in Kd cells and, as already reported, as a 2 kb transcript in DU 528 cells. Importantly, a 5 kb <jats:italic>SCL<\/jats:italic> transcript was also detected in immature nonlymphoid hematopoietic cells but not in normal mature T cells, suggesting that it might correspond to the normal <jats:italic>SCL<\/jats:italic> transcript. Taken together, our data support the notion that the involvement of the <jats:italic>SCL<\/jats:italic> gene in the leukemogenic process may occur through overexpression of an apparently normal transcript (Kd cells) or expression of a truncated RNA (DU 528 cells).<\/jats:p>","DOI":"10.1002\/gcc.2870010303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:38:25Z","timestamp":1172097505000},"page":"194-208","source":"Crossref","is-referenced-by-count":89,"title":["Two distinct mechanisms for the <i>SCL<\/i> gene activation in the t(1;14) translocation of T\u2010cell leukemias"],"prefix":"10.1002","volume":"1","author":[{"given":"Olivier","family":"Bernard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jonveaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorra","family":"Cherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Gisselbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Mauchauffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian\u2010Jacques","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Mathieu\u2010Mahul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90243-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02993.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.6.2031"},{"key":"e_1_2_1_5_1","first-page":"195","article-title":"Molecular 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