{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:10:31Z","timestamp":1698041431839},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5979,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient with Philadelphia (Ph<jats:sup>1<\/jats:sup>)\u2010negative, breakpoint cluster region (bcr)\u2010positive chronic myeloid leukemia (CML) is reported. Pulsed\u2010field gel electrophoretic analysis demostrated the comigration of both <jats:italic>ABL<\/jats:italic> and <jats:italic>BCR<\/jats:italic> sequences on the same <jats:italic>Bss<\/jats:italic>1\u2013111 and <jats:italic>Sac<\/jats:italic>11 fragment. Moreover, in situ hybridization studies demonstrated that <jats:italic>ABL<\/jats:italic> sequences had been moved from band 9q34 to 22q11 and that the additional t(12;12)(q13;p12) was not involved in the <jats:italic>ABL\/BCR<\/jats:italic> related translocation. Neverthless, a possible role of oncogenes or regulatory sequences activated or inhibited by the additional translocation cannot be excluded.<\/jats:p>","DOI":"10.1002\/gcc.2870010405","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:54:12Z","timestamp":1172098452000},"page":"284-288","source":"Crossref","is-referenced-by-count":3,"title":["Molecular and cytogenetic studies of a patient with philadelphia\u2010negative, <i>BCR<\/i>\u2010positive chronic myeloid leukemia and t(12;12)(q13;p12)"],"prefix":"10.1002","volume":"1","author":[{"given":"Alfonso","family":"Zaccaria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Testoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Tassinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bommina","family":"Celso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly S.","family":"Emanuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Budarf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Saglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Guerrasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Barletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Peschle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sante","family":"Tura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.6.2175"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90046-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/j.1460-2075.1985.tb03683.x","article-title":"c\u2010abl and ber are rearranged in a Ph\u2010negative CML patient","volume":"4","author":"Bartram CR","year":"1985","journal-title":"EMBO J"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.14.5647"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90594-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90381-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1182\/blood.V68.4.957.957","article-title":"Rearrangement of the bcr gene in Philadelphia chromosome\u2010negative chronic myeloid leukemia","volume":"68","author":"Ganesan TS","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90077-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327364"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/306239a0"},{"key":"e_1_2_1_12_1","volume-title":"Birth Defects: Original Article Series","author":"ISCN","year":"1985"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861101)58:9<2023::AID-CNCR2820580912>3.0.CO;2-H"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90438-0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-5-673"},{"key":"e_1_2_1_16_1","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Maniatis TE","year":"1982"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90301-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/315550a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1182\/blood.V73.4.1038.1038","article-title":"Cytogenetic and molecular analysis in Philadelphia negative CML","volume":"73","author":"van der Plas DC","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107163050304"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90087-3"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870010405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870010405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:34:35Z","timestamp":1698006875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870010405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1002\/gcc.2870010405"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870010405","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}