{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:48Z","timestamp":1762100628826},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 68\u2010year\u2010old man presented with t(4;11)(q21;q23). B\u2010lineage acute lymphoblastic leukemia (ALL) which was negative for C\u2010ALL antigen and TdT. Clonal evolution to five different, but related karyotypes, in which chromosomal material distal either to 1q11 or 1q21 was translocated to the terminal regions of 4q\u2010, 11q, 16q, and 19p resulted in partial or total trisomy of 1q. The patient, having achieved a short remission, died 14 weeks after diagnosis. Five reports of jumping translocations in hematological malignancies, four with B\u2010lineage malignancy, are reviewed. One (four cases) or both (one case) of the same 1q breakpoints were consistently found and 11q and 16q were repeatedly involved. Such cases, having multiple subclones with trisomy 1q, may form a distinct subgroup of ALL.<\/jats:p>","DOI":"10.1002\/gcc.2870020104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:53:53Z","timestamp":1172098433000},"page":"14-17","source":"Crossref","is-referenced-by-count":32,"title":["Leukemia characterized by multiple sub\u2010clones with unbalanced translocations involving different telomeric segments: Case report and review of the literature"],"prefix":"10.1002","volume":"2","author":[{"given":"Caroline A.","family":"Shippey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Layton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna M.","family":"Secker\u2010Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1182\/blood.V67.2.415.415","article-title":"Chromosomal abnormalities identify high\u2010risk and low\u2010risk patients with acute lymphoblastic leukaemia","volume":"67","author":"Bloomfield CD","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90015-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291396"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132633"},{"key":"e_1_2_1_6_1","first-page":"170","article-title":"The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukaemia: A study of 500 cases","volume":"3","author":"Janossy G","year":"1988","journal-title":"Leukemia"},{"key":"e_1_2_1_7_1","volume-title":"Catalog of Chromosome Aberrations in Cancer","author":"Mitelman F","year":"1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840701)54:1<48::AID-CNCR2820540112>3.0.CO;2-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90085-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5729"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3941901"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90119-5"},{"key":"e_1_2_1_13_1","unstructured":"ShinoharaT NomuraT(1988)\u201cJumping translocation\u201d of a trisomic whole q arm of chromosome # 1 in an acute lymphoblastic leukaemia. Abstract XXII Congress of the International Society of Haematology."},{"key":"e_1_2_1_14_1","first-page":"195","article-title":"Isochromosome 9q in acute lymphoblastic leukemia: A new non\u2010random finding","volume":"3","author":"Shippey CA","year":"1989","journal-title":"Leukemia"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910270309"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90077-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/blood.V63.4.818.818","article-title":"Burkitt's lymphoma in AIDS: Cytogenetic study","volume":"63","author":"Whang\u2010Peng J","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(80)90078-3"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870020104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870020104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T07:19:58Z","timestamp":1697959198000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870020104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1002\/gcc.2870020104"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870020104","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}