{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:35Z","timestamp":1762100615062},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although several independent series of non\u2010Hodgkin's lymphomas (NHLs) have been subjected to cytogenetic studies or analyses of lineages by assaying for clonal immunophenotypes and clonal rearrangements affecting immunoglobulin (<jats:italic>IG<\/jats:italic>) and T\u2010cell receptor (<jats:italic>TCR<\/jats:italic>) genes, no published reports exist of series of non\u2010B\u2010cell NHLs on which cytogenetic, immunohistochemical, and <jats:italic>IG<\/jats:italic> and <jats:italic>TCR<\/jats:italic> gene rearrangement studies have been undertaken together. Among 434 NHLs ascertained prospectively between January 1984 and December 1988 at the Memorial Sloan\u2010Kettering Cancer Center, 278 cases with clonal chromosome abnormalities were identified. Of the latter, 20 were non\u2010B\u2010cell NHLs, which in turn comprised 15 peripheral T\u2010cell lymphomas (PTCLs) and 5 lymphomas of uncertain lineage (LULs). The LULs either were bigenotypic, had discordant immunophenotype and immunogenotype, or showed no evidence of B\u2010cell, T\u2010cell, or histiocytic derivation. Of the 15 PTCLs, eight expressed the Ki\u20101 antigen and four of these had translocations involving the band 5q35 [t(5q35)]. Of the five LULs, four expressed the Ki\u20101 antigen and one of these had a translocations involving band 5q35. Previous studies have associated t(5q35) with Ki\u20101 positive NHLs characterized histologically by a pleomorphic diffuse large cell morphology. In our series of 12 Ki\u2010positive non\u2010B\u2010cell NHLs, five (42%) had a 5q35 translocation. They were histologically indistinguishable from the subset without the translocation. The frequent lineage uncertainty exhibited by Ki\u20101 positive NHLs of similar histology and cytogenetic abnormalities suggests their derivation from an early uncommitted lymphoid cells.<\/jats:p>","DOI":"10.1002\/gcc.2870020106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:53:53Z","timestamp":1172098433000},"page":"27-35","source":"Crossref","is-referenced-by-count":33,"title":["Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral t\u2010cell lymphomas and lymphomas of uncertain lineage, including 12 Ki\u2010I positive lymphomas"],"prefix":"10.1002","volume":"2","author":[{"given":"Salah A. D.","family":"Ebrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ladanyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvas B.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Offit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh C.","family":"Jhanwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Filippa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S. 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