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Unlike classic t\u2010AML, which frequently has abnormalities of chromosomes 5 and\/or 7, this new subtype is characterized by rearrangements involving band q23 of chromosome 11, most commonly a 9;11 translocation. The majority of patients with this subtype of t\u2010AML had prior cytotoxic therapy with topoisomerase II\u2010reactive drugs including anthracyclines, epipodophyllotoxins, or actinomycin D, combined with either an alkylating agent or cisplatin. This association of prior therapy which includes topoisomerase II\u2010reactive agents and a rapidly appearing t\u2010AML involving the monocytic line and chromosome 11 requires additional study.<\/jats:p>","DOI":"10.1002\/gcc.2870020110","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:53:53Z","timestamp":1172098433000},"page":"53-58","source":"Crossref","is-referenced-by-count":37,"title":["Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy\u2010related monocytic leukemia with a 9;11 translocation"],"prefix":"10.1002","volume":"2","author":[{"given":"Kathy S.","family":"Albain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Ullirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90030-X"},{"key":"e_1_2_1_3_1","first-page":"5455","article-title":"Pharmacological, molecular, and cytogenetic analysis of \u201catypical\u201d multidrug\u2010resistant human leukemia cells","volume":"47","author":"Beck WT","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891215)64:12<2459::AID-CNCR2820641210>3.0.CO;2-T"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00424a026"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197303)31:3<543::AID-CNCR2820310308>3.0.CO;2-M"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(87)90081-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-9-740"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90136-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1200\/JCO.1987.5.8.1304","article-title":"Translocation t(9;11)(p21;q23) with acute myelomonocytic leukemia after chemotherapy for osteosatcoma: Good response to antileukemic drugs [letter]","volume":"5","author":"Fenaux P","year":"1987","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.12.1640"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(84)80019-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(84)80009-6"},{"key":"e_1_2_1_14_1","first-page":"1939","article-title":"Cross\u2010resistance in a Chinese hamster ovary cell line: Loss of drug\u2010stimulated DNA cleavage activity","volume":"46","author":"Glisson B","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_1","first-page":"94","article-title":"Chromosome analysis of 63 cases of secondary nonlymphoid blood disorders: A cooperative study","volume":"12","author":"Groupe Fran\u00e7ais de Cytogenetique Hematologique","year":"1984","journal-title":"Cancer Genet Cytogenet"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1200\/JCO.1987.5.8.1135","article-title":"Second malignancies from adjuvant chemotherapy? 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