{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:09:10Z","timestamp":1770502150536,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5795,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The t(11;14)(q13;q32) is a recurring translocation associated with some chronic B\u2010cell lymphocytic malignancies; the putative protooncogene <jats:italic>BCL1<\/jats:italic>, located at the chromosome band 11q13, can be involved during the translocation process. In order to determine if <jats:italic>BCL1<\/jats:italic> rearrangement is associated with a particular subtype of lymphoma, we analysed 131 B\u2010cell non\u2010Hodgkin's lymphoma samples by Southern blot analysis, using a <jats:italic>BCL1<\/jats:italic> probe. The <jats:italic>BCL1<\/jats:italic> locus was rearranged in 9 out of 25 (36%) cases of intermediate lymphocytic cell lymphomas (ILL), in 1 out of 8 cases of diffuse small cleaved cell lymphoma, in 1 out of 12 cases of diffuse mixed cell lymphoma, and in 1 out of 21 cases of diffuse large cell lymphoma. In contrast, <jats:italic>BCL1<\/jats:italic> was never found rearranged in any of the 46 follicular lymphomas analysed. The <jats:italic>BCL2<\/jats:italic> gene was in germ\u2010line configuration in all ILL. Sequential hybridization of Southern blots with JH, C\u03bc, and <jats:italic>BCL1<\/jats:italic> probes identified comigrating fragments in only one case of ILL, which suggests that, in all the other cases, either the rearrangement of <jats:italic>BCL1<\/jats:italic> did not result from a t(11;14) translocation or the break on chromosome 14 occurred outside the JH or C\u03bc regions. These results indicate that rearrangement of the <jats:italic>BCL1<\/jats:italic> locus may be closely associated with ILL and could be considered as a genotypic marker of this lymphoma subtype.<\/jats:p>","DOI":"10.1002\/gcc.2870020310","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:52:20Z","timestamp":1172098340000},"page":"223-226","source":"Crossref","is-referenced-by-count":39,"title":["Break in the <i>BCL1<\/i> locus is closely associated with intermediate lymphocytic lymphoma subtype"],"prefix":"10.1002","volume":"2","author":[{"given":"Ruth","family":"Rimokh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Cornillet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Wahbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Rouault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Ffrench","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul\u2010Andr\u00e9","family":"Bryon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myf\u00e8ne","family":"Gadoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Gentilhomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Germain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Magaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80070-2"},{"key":"e_1_2_1_3_1","first-page":"223","volume-title":"Cellular Oncogene Activation","author":"Bornkamm GW","year":"1988"},{"key":"e_1_2_1_4_1","first-page":"2975","article-title":"Nonrandom chromosome abnormalities in lymphoma","volume":"43","author":"Bloomfield CD","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0769-2625(84)81192-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7439"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.1.315"},{"key":"e_1_2_1_8_1","unstructured":"CornilletP RimokhR BergerF FfrenchM RouaultJP WahbiK BryonPA GentilhommeO CoiffierB GermainD MagaudJP.Involvement of the bcl\u20102 gene in 131 cases of B non\u2010Hodgkin's lymphomas. Analysis of correlations with immunological findings and cell cycle. Submitted."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1182\/blood.V70.5.1554.1554","article-title":"Correlation of chromosomal abnormalities with histologic and immunologic characteristics in non\u2010Hodgkin's lymphoma and adult T cell leukemia","volume":"70","author":"Fifth International Workshop on chromosomes in leukemialymphoma","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_10_1","first-page":"3119","article-title":"Chromosome abnormalities in poorly differentiated lymphocytic lymphoma","volume":"39","author":"Fukuhara S","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","first-page":"343","article-title":"bcl\u20101 gene rearrangement in B cell lymphoma","volume":"2","author":"Ince C","year":"1988","journal-title":"Leukemia"},{"key":"e_1_2_1_12_1","first-page":"929","article-title":"Molecular analysis of breaks in bcl\u20101 proto\u2010oncogene in B\u2010cell rymphomas with abnormalities of 11q13","volume":"4","author":"Koduru PRK","year":"1989","journal-title":"Oncogene"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1182\/blood.V66.6.1414.1414","article-title":"There are differences in cytogenetic abnormalities among histologic subtypes of the non\u2010Hodgkin's lymphomas","volume":"66","author":"Levine EG","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_14_1","first-page":"31","article-title":"Molecular cloning of the chromosomal breakpoint isolated from a B\u2010prolymphocytic leukemia patient carrying t(11;14)(q13;q32)","volume":"41","author":"Louie E","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.4049\/jimmunol.141.11.3994","article-title":"Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia","volume":"141","author":"Meeker T","year":"1988","journal-title":"J Immunol"},{"key":"e_1_2_1_16_1","volume-title":"Catalog of Chromosome Aberrations in Cancer","author":"Mitelman F","year":"1988"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/blood.V57.3.444.444","article-title":"Proliferation differentiation, and cytogenetics of chronic leukemic B lymphocytes cultured with mitomycin\u2010treated normal cells","volume":"57","author":"Nowell PC","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_18_1","first-page":"99","article-title":"Chromosome abnormalities at 11q13 in B cell tumors","volume":"3","author":"Rabbitts P","year":"1988","journal-title":"Oncogene"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb06270.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6093263"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/315340a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90017-7"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.6.1617.1617"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90084-0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701083160204"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870020310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870020310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T07:13:21Z","timestamp":1697958801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870020310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["10.1002\/gcc.2870020310"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870020310","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}