{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:51:41Z","timestamp":1790553101611,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5795,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The t(1;19) chromosomal translocation in acute lymphoblastic pre\u2010B cell leukemias involves the gene <jats:italic>E2A<\/jats:italic> for helix\u2010loop\u2010helix (HLH) proteins E12 and E47, ubiquitous transcriptional proteins implicated in the regulation of various lymphoid and nonlymphoid genes. To characterize the molecular features of the t(1;19)(q23;p13) translocation, we molecularly cloned breakpoint DNA from t(1;19)\u2010carrying pre\u2010B cell leukemias. In all cases, breakpoints on chromosome 19 occurred within 2 kb of each other in a single intron of the <jats:italic>E2A<\/jats:italic> gene. This clustered arrangement resulted in specific truncation of the <jats:italic>E2A<\/jats:italic> gene and transcript, with loss of sequences encoding the basic DNA\u2010binding and HLH dimerization motifs from the derivative 19 chromosome. In contrast, breakpoints on chromosome 1 were distributed over a large region and could not be linked to exonic sequences of the <jats:italic>PBX1<\/jats:italic> gene, although identical chromosome 1 sequences are joined to <jats:italic>E2A<\/jats:italic> sequences in 1;19 fusion transcripts. These data show that the 1;19 translocation consistently results in exchange of 3\u2032 exons encoding the HLH motifs of <jats:italic>E2A<\/jats:italic> with DNA from chromosome 1 to form a fusion gene on the derivative 19 chromosome.<\/jats:p>","DOI":"10.1002\/gcc.2870020313","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:52:20Z","timestamp":1172098340000},"page":"239-247","source":"Crossref","is-referenced-by-count":40,"title":["Molecular analysis of the t(1;19) breakpoint cluster region in pre\u2010b cell acute lymphoblastic leukemias"],"prefix":"10.1002","volume":"2","author":[{"given":"Julia O.","family":"Mellentin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamison","family":"Nourse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen 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